INT279580

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Context Info
Confidence 0.48
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.15
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (MBL2) extracellular region (MBL2)
Anatomy Link Frequency
plasma 2
neutrophils 2
MBL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Antihistamine 2 59.12 Quite High
cytokine 12 54.08 Quite High
agonist 33 50.00 Quite Low
Inflammation 25 46.08 Quite Low
Pain 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 4 99.64 Very High Very High Very High
Flavivirus Infection 80 99.28 Very High Very High Very High
Dengue 104 98.00 Very High Very High Very High
Infection 64 96.48 Very High Very High Very High
Mrsa Infection 10 88.88 High High
Bacterial Meningitis 2 73.36 Quite High
Common Cold 2 71.92 Quite High
Convalescence 4 71.60 Quite High
Lower Respiratory Tract Infection 2 65.36 Quite High
Staphylococcus Infection 6 63.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The activity of the LP was evaluated by measuring the levels of oligomerized MBL, and a significant increase of MBL oligomerization was found in the DHF patients as compared to the DF patients during the acute phase of infection, which might have contributed to the elevated C4a level.
Positive_regulation (increase) of MBL Binding (oligomerization) of associated with flavivirus infection, dengue and infection
1) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.49 Pain Relevance 0
The MBL-MASP complex has a significant role in increasing C3b deposition on the surface of S. aureus [22], contributing to an increase in its engulfment by neutrophils.
Positive_regulation (increasing) of MBL Binding (complex) of in neutrophils
2) Confidence 0.41 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2856528 Disease Relevance 0.49 Pain Relevance 0.06
Recent reports have identified a mutation in exon 3 of this gene leading to the exchange of aspartate with glycine at position 105 (D105G) within the CUB1 domain, causing impaired binding to MBL, and also low circulating plasma levels of MASP-2 [11,12].
Positive_regulation (causing) of MBL Binding (binding) of in plasma
3) Confidence 0.38 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2856528 Disease Relevance 0.07 Pain Relevance 0.03
M TRO, only two genes involved in oxidative stress, namely, mannose binding lectin 2 (MBL2) and serum/glucocorticoid regulated kinase 2 (SGK2), were induced.
Positive_regulation (induced) of MBL2 Binding (binding) of associated with stress
4) Confidence 0.23 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.10 Pain Relevance 0

General Comments

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