INT279598

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Context Info
Confidence 0.07
First Reported 2009
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 2.91
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rax)
Anatomy Link Frequency
blood 1
Rax (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 27 91.32 High High
Inflammation 40 82.12 Quite High
anesthesia 5 17.84 Low Low
imagery 5 16.40 Low Low
Glutamate 14 5.00 Very Low Very Low Very Low
nMDA receptor 11 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
Angina 6 5.00 Very Low Very Low Very Low
abdominal pain 5 5.00 Very Low Very Low Very Low
gABA 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 336 99.76 Very High Very High Very High
Diabetic Retinopathy 77 89.92 High High
Disorder Of Lipid Metabolism 4 86.84 High High
INFLAMMATION 40 82.12 Quite High
Weight Loss 1 80.76 Quite High
Death 5 78.44 Quite High
Syndrome 82 67.08 Quite High
Ocular Toxicity (including Many Sub-types) 8 61.44 Quite High
Disease 37 57.12 Quite High
Apoptosis 20 48.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because the Rx orders in the real data set were incomplete and sporadic, we did not generate the synthetic Rx orders table.
Neg (not) Gene_expression (synthetic) of Rx
1) Confidence 0.07 Published 2010 Journal BMC Med Inform Decis Mak Section Body Doc Link PMC2972239 Disease Relevance 0.38 Pain Relevance 0
The effect of diabetes on the rat retinal protein levels of GluR1, GluR2, GluR2/3, and GluR4 receptor subunits was examined by western blot analysis.
Gene_expression (levels) of retinal protein associated with diabetes mellitus
2) Confidence 0.02 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 0.80 Pain Relevance 0.05
These results expand the understanding of the changes in retinal protein expression occurring with diabetes and their responsiveness to normalization of blood glucose through insulin therapy.
Gene_expression (expression) of retinal protein in blood associated with diabetes mellitus
3) Confidence 0.02 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3020973 Disease Relevance 0.29 Pain Relevance 0.04
The results of the combined proteomic, transcriptomic, and confirmation experiments both validate previously reported changes in retinal protein expression with diabetes and identify novel changes.
Gene_expression (expression) of retinal protein associated with diabetes mellitus
4) Confidence 0.02 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.49 Pain Relevance 0
This study identified a number of retinal protein expression changes with diabetes.
Gene_expression (expression) of retinal protein associated with diabetes mellitus
5) Confidence 0.02 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.16 Pain Relevance 0
Availability of human post-mortem retinal samples is limited, but animal model systems offer the potential to examine diabetes-induced alterations in retinal protein expression.
Gene_expression (expression) of retinal protein associated with diabetes mellitus
6) Confidence 0.02 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.79 Pain Relevance 0.06

General Comments

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