INT279628

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Context Info
Confidence 0.04
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 13
Disease Relevance 6.10
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ar) nucleus (Ar) enzyme binding (Ar)
DNA binding (Ar) transcription factor binding (Ar) cytoplasm (Ar)
Anatomy Link Frequency
PC-3 3
glands 2
meibomian gland 1
lacrimal 1
Ar (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 36 88.08 High High
agonist 9 83.44 Quite High
palliative 9 70.96 Quite High
antagonist 26 33.72 Quite Low
Inflammation 20 5.00 Very Low Very Low Very Low
Neuropeptide 18 5.00 Very Low Very Low Very Low
isoflurane 18 5.00 Very Low Very Low Very Low
imagery 18 5.00 Very Low Very Low Very Low
anesthesia 9 5.00 Very Low Very Low Very Low
cva 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 279 99.50 Very High Very High Very High
Disorders Of The Lacrimal System 340 98.80 Very High Very High Very High
Eyelid Disease 8 98.28 Very High Very High Very High
Cancer 261 97.96 Very High Very High Very High
Severe Combined Immunodeficiency 45 97.76 Very High Very High Very High
Disease 27 96.92 Very High Very High Very High
Starvation 9 95.88 Very High Very High Very High
Metastasis 54 95.40 Very High Very High Very High
Hyperplasia 9 92.36 High High
Stress 13 79.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Androgen deficiency, in turn, has been linked to lacrimal and meibomian gland dysfunction, and a corresponding aqueous tear deficiency and evaporative dry eye [22-26,28-30].
Negative_regulation (deficiency) of Androgen in lacrimal associated with disorders of the lacrimal system and eyelid disease
1) Confidence 0.04 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728565 Disease Relevance 0.90 Pain Relevance 0
In addition, a number of the androgen-regulated genes in female glands were altered in the opposite direction by 17?
Negative_regulation (number) of androgen in glands
2) Confidence 0.04 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2728565 Disease Relevance 0.47 Pain Relevance 0
In addition, a number of the androgen-regulated genes in female glands were altered in the opposite direction by 17?
Negative_regulation (number) of androgen in glands
3) Confidence 0.04 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728565 Disease Relevance 0.53 Pain Relevance 0
Of note, in hormono-insensitive PC-3 cells, neither androgen deprivation in vitro nor castration in vivo had any effect on tumor growth and SphK1 activity.
Neg (neither) Negative_regulation (deprivation) of androgen in PC-3 associated with cancer
4) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0.61 Pain Relevance 0
Remarkably, under androgen deprivation conditions, a similar increase in cAMP intracellular levels was observed, which could not be blocked by pharmacological inhibition of SphK1 (Fig. 7D).
Negative_regulation (deprivation) of androgen
5) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0.13 Pain Relevance 0.11
On the contrary, androgen deprivation did not alter the growth of PC-3 hormono-refractory (HR) cells whose growth was only altered by serum starvation (Fig. 1C).When compared to FBS conditions, androgen depletion in LNCaP induced a notable decrease in SphK1 activity within the first 24 h (Fig. 1D, left panel).
Negative_regulation (deprivation) of androgen in PC-3 associated with starvation
6) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0.24 Pain Relevance 0.03
Androgens regulate prostate cancer cell proliferation, and androgen deprivation therapy is the standard of care in the management of patients with advanced disease.
Negative_regulation (deprivation) of androgen associated with disease and reprotox - general 1
7) Confidence 0.03 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2779655 Disease Relevance 0.46 Pain Relevance 0
The instrumental role of SphK1 inhibition in reduced cell growth was confirmed by cell viability assays, which showed that LNCaP overexpressing SphK1 were markedly less sensitive to the effects of androgen depletion (Fig. 3B).
Negative_regulation (depletion) of androgen
8) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0.34 Pain Relevance 0
Because an inhibition of SphK1 was observed during short-term androgen deprivation in vitro (Fig. 1D) and in vivo (Fig. 2B), we verified whether transfection of LNCaP cells with SphK1 might render these cells more resistant to androgen depletion.
Negative_regulation (deprivation) of androgen
9) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0.69 Pain Relevance 0
Based on our previous observations that SphK1 activity upon androgen deprivation was only transiently inhibited with a significant rebound within 4 days of incubation in CSS medium (Fig. 1D), we then analyzed the SphK1 activity up to 42 days during the NE transdifferentiation process.
Negative_regulation (deprivation) of androgen
10) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0.07 Pain Relevance 0
The transition to the androgen refractory state during chronic androgen depletion is characterized in vitro by a loss of response of androgen-deprived cells to either FBS or DHT [20].
Negative_regulation (depletion) of androgen
11) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0.32 Pain Relevance 0.12
The effect of androgen deprivation was next examined in vivo using a surgical orthotopic implantation (SOI) of LNCaP and PC-3 cells overexpressing GFP [36].
Negative_regulation (deprivation) of androgen in PC-3
12) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0.45 Pain Relevance 0
Androgen deficiency, in turn, has been linked to lacrimal and meibomian gland dysfunction, and a corresponding aqueous tear deficiency and evaporative dry eye [22-26,28-30].
Negative_regulation (deficiency) of Androgen in meibomian gland associated with disorders of the lacrimal system and eyelid disease
13) Confidence 0.01 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728565 Disease Relevance 0.90 Pain Relevance 0

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