INT279705

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Context Info
Confidence 0.08
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CALM3, TRPV4) nucleoplasm (CALM3) small molecule metabolic process (CALM3)
carbohydrate metabolic process (CALM3) transmembrane transport (TRPV4) cytoplasm (CALM3)
CALM3 (Homo sapiens)
TRPV4 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 2 100.00 Very High Very High Very High
TRP channel 9 99.12 Very High Very High Very High
agonist 3 50.16 Quite High
imagery 3 5.00 Very Low Very Low Very Low
nociceptor 3 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Mechanosensation 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Helminth Infection 14 45.76 Quite Low
Sprains And Strains 9 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Heart Rate Under Development 2 5.00 Very Low Very Low Very Low
Arterial-venous Cerebral Malformations 1 5.00 Very Low Very Low Very Low
Nociception 1 5.00 Very Low Very Low Very Low
Loss Of Sense Of Smell 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Within the TRPV subfamily, CaM-dependent regulation has been shown for the capsaicin and temperature-sensitive TRPV1 [3], [6], [7], temperature-sensitive TRPV3 [8], the highly Ca2+-selective epithelial Ca2+ channels TRPV5 and TRPV6 [4], [9], [10], and TRPV4 [11].
CaM Regulation (regulation) of TRPV4 associated with qutenza
1) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0.16
Interestingly, TRPV4 and 6 are both positively regulated by CaM.
CaM Regulation (regulated) of TRPV4
2) Confidence 0.01 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2729924 Disease Relevance 0 Pain Relevance 0.17

General Comments

This test has worked.

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