INT27973

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Context Info
Confidence 0.65
First Reported 1989
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 31
Total Number 32
Disease Relevance 15.70
Pain Relevance 3.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ACOT1) lipid metabolic process (ACOT1) cytoplasm (ACOT1)
Anatomy Link Frequency
plasma 2
tendons 2
cholinergic neurons 2
reticular formation 1
aorta 1
ACOT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 56 98.48 Very High Very High Very High
Angina 13 97.74 Very High Very High Very High
imagery 22 96.44 Very High Very High Very High
Osteoarthritis 3 96.28 Very High Very High Very High
rheumatoid arthritis 3 95.52 Very High Very High Very High
tetrodotoxin 2 94.40 High High
Pain 31 91.56 High High
Inflammation 27 89.96 High High
aspirin 4 89.40 High High
Neurotransmitter 14 87.68 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 29 99.86 Very High Very High Very High
Dilated Cardiomyopathy 280 99.44 Very High Very High Very High
Tendinopathy 31 99.34 Very High Very High Very High
Diabetes Mellitus 280 99.20 Very High Very High Very High
Amnesia 7 98.96 Very High Very High Very High
Alzheimer's Dementia 49 98.40 Very High Very High Very High
Hypersensitivity 32 98.12 Very High Very High Very High
Cognitive Disorder 152 97.96 Very High Very High Very High
Inflammatory Bowel Disease 3 97.92 Very High Very High Very High
Cv General 3 Under Development 13 97.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, the production of ACh in local cells in the tissues represents an important extra supply of the transmitter.
Gene_expression (production) of ACh
1) Confidence 0.65 Published 2009 Journal Life Sci. Section Abstract Doc Link 19409915 Disease Relevance 0.58 Pain Relevance 0.42
There is evidence of both acetylcholine (ACh) production and a marked existence of muscarinic (M2) ACh receptors in these situations.
Gene_expression (production) of ACh
2) Confidence 0.65 Published 2009 Journal Life Sci. Section Abstract Doc Link 19409915 Disease Relevance 0.70 Pain Relevance 0.45
We have investigated the rates of acetylcholine (ACh) synthesis and release in LA-N-2 cells in order to characterize them as a potential model of cholinergic neurons.
Gene_expression (synthesis) of ACh in cholinergic neurons
3) Confidence 0.52 Published 1989 Journal Brain Res. Section Abstract Doc Link 2702472 Disease Relevance 0.07 Pain Relevance 0
The data demonstrate that LA-N-2 cells exhibit some properties similar to cholinergic neurons and may therefore be useful for studies of ACh synthesis and release.
Gene_expression (synthesis) of ACh in cholinergic neurons
4) Confidence 0.52 Published 1989 Journal Brain Res. Section Abstract Doc Link 2702472 Disease Relevance 0.07 Pain Relevance 0.09
There is evidence of both acetylcholine (ACh) production and a marked existence of muscarinic (M2) ACh receptors in these situations.
Gene_expression (production) of ACh
5) Confidence 0.50 Published 2009 Journal Life Sci. Section Abstract Doc Link 19409915 Disease Relevance 0.71 Pain Relevance 0.45
In the non-CSA group, the NOx uptake across the coronary circulation correlated with the endothelium-dependent vasoresponse to Ach (r = -0.61, p < 0.05) and NOx levels of the aorta also correlated (r = -0.72, p < 0.005), which suggested the compensatory increase of systemic NOx levels for impaired endothelial function.
Gene_expression (levels) of Ach in aorta associated with angina
6) Confidence 0.50 Published 2004 Journal Cardiovasc Drugs Ther Section Abstract Doc Link 15229386 Disease Relevance 0.53 Pain Relevance 0.39
In contrast, there were no significant differences between the two groups in terms of the change in coronary epicardial diameter in response to several doses of ACh infusion after l-NMMA except for 3 µg ACh infusion (Cohen's d =0.04 (0.3 µg ACh), 1.8 (3 µg ACh), and 0.6 (30 µg ACh); Table 3).


Neg (except) Gene_expression (infusion) of ACh
7) Confidence 0.43 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2995954 Disease Relevance 0.56 Pain Relevance 0
baseline) × 100/ACh infusion) in both the DCM and the control groups was changed in a concentration-dependent manner.
Gene_expression (infusion) of ACh associated with dilated cardiomyopathy
8) Confidence 0.43 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2995954 Disease Relevance 0.57 Pain Relevance 0
Figure 3 shows representative tracings of the change in plasma NO concentration in the GCV after intracoronary infusion of ACh at different concentrations (0.3, 3, and 30 µg) and infusion of ACh immediately after l-NMMA in the DCM and control groups.
Gene_expression (infusion) of ACh in plasma associated with dilated cardiomyopathy
9) Confidence 0.43 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2995954 Disease Relevance 0.47 Pain Relevance 0
The ratio of APV increase by ACh ((ACh infusion?
Gene_expression (infusion) of ACh
10) Confidence 0.43 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2995954 Disease Relevance 0.52 Pain Relevance 0
Thus, FMD and vasomotion after ACh injection may not be adequate parameters of NO bioavailability and endothelial function.
Gene_expression (injection) of ACh associated with bioavailability
11) Confidence 0.43 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2995954 Disease Relevance 0.13 Pain Relevance 0.08
Figure 3 shows representative tracings of the change in plasma NO concentration in the GCV after intracoronary infusion of ACh at different concentrations (0.3, 3, and 30 µg) and infusion of ACh immediately after l-NMMA in the DCM and control groups.
Gene_expression (infusion) of ACh in plasma associated with dilated cardiomyopathy
12) Confidence 0.43 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2995954 Disease Relevance 0.42 Pain Relevance 0
The ratio of APV increase by ACh ((ACh infusion?
Gene_expression (infusion) of ACh
13) Confidence 0.43 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2995954 Disease Relevance 0.52 Pain Relevance 0
Although we and others (Pellaton et al 2002) have observed that the reductions of ACh- and SNP-induced relaxations are similar in degree, the heat-induced relaxation was larger than either of the individual responses to ACh and SNP.
Gene_expression (reductions) of ACh
14) Confidence 0.41 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515430 Disease Relevance 0.78 Pain Relevance 0
We made similar observations in the present investigation, as both the Ach and SNP responses were blunted in the presence of NIDDM.
Gene_expression (blunted) of Ach associated with diabetes mellitus
15) Confidence 0.20 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663449 Disease Relevance 0.59 Pain Relevance 0.09
Ach and SNP were applied transcutaneously by iontophoresis and skin blood flow changes measured by laser Doppler imaging.
Gene_expression (applied) of Ach in skin associated with imagery
16) Confidence 0.18 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663449 Disease Relevance 0.67 Pain Relevance 0.09
Three different doses of current charge density were tested for the iontophoresis of Ach.
Gene_expression (iontophoresis) of Ach
17) Confidence 0.18 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663449 Disease Relevance 0.82 Pain Relevance 0
Response to iontophoretically applied Ach and SNP (Table 3)
Gene_expression (applied) of Ach
18) Confidence 0.18 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663449 Disease Relevance 0.77 Pain Relevance 0
ACh is produced in cholinergic neurons by the action of choline acetyltransferase, concentrated in vesicles, and released from the presynaptic cell following depolarization.
Gene_expression (produced) of ACh in vesicles
19) Confidence 0.13 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647161 Disease Relevance 0.61 Pain Relevance 0.04
The general mechanism of AChEI is to increase the brain availability of acetylcholine (ACh) through an inhibition of the enzyme acetylcholinesterase (AChE).
Gene_expression (mechanism) of AChEI in brain
20) Confidence 0.13 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647161 Disease Relevance 0.71 Pain Relevance 0.04

General Comments

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