INT279806

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Context Info
Confidence 0.05
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.00
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TYMS) mitochondrion (TYMS) small molecule metabolic process (TYMS)
aging (TYMS) cytoplasm (TYMS) cytosol (TYMS)
TYMS (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 130 64.24 Quite High
palliative 1 49.40 Quite Low
complementary and alternative medicine 3 36.16 Quite Low
withdrawal 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 51 99.92 Very High Very High Very High
Cancer 55 98.78 Very High Very High Very High
Breast Cancer 50 91.24 High High
Colon Cancer 1 85.52 High High
Small Cell Lung Cancer 63 82.56 Quite High
Cirrhosis 1 57.64 Quite High
Liver Cancer 1 56.56 Quite High
Lung Cancer 10 28.32 Quite Low
Immunotherapy Of Cancer 2 20.16 Low Low
Disease 8 15.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These free E2Fs subsequently bind to target proliferative promoters like cyclin E, thymidylate synthase (TS), cdc25A and cdc6, which regulate cell cycle progression [31], [32].
Regulation (target) of thymidylate synthase
1) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.08 Pain Relevance 0.12
5-fluorouracil (5-FU) is a DNA damaging drug that is commonly used as a chemotherapeutic agent that inhibits cancer growth by initiating apoptosis. 5-FU initiates apoptosis by targeting thymidylate synthase (TS), and by direct incorporation of 5-FU metabolites into DNA and RNA [13].
Regulation (targeting) of thymidylate synthase associated with cancer and apoptosis
2) Confidence 0.02 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2730474 Disease Relevance 0.92 Pain Relevance 0

General Comments

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