INT279809

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.08
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ERBB3) extracellular space (ERBB3) extracellular region (ERBB3)
plasma membrane (ERBB3) nucleus (ERBB3)
Anatomy Link Frequency
MCF-7 1
MDA-MB-231 1
ERBB3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 6 5.00 Very Low Very Low Very Low
complementary and alternative medicine 6 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 144 100.00 Very High Very High Very High
Osteoporosis 12 98.76 Very High Very High Very High
Cancer 158 95.52 Very High Very High Very High
Osteolysis 4 94.16 High High
Metastasis 54 53.28 Quite High
Pleural Effusion 2 50.04 Quite High
Apoptosis 92 50.00 Quite Low
Adenocarcinoma 2 43.52 Quite Low
Death 26 5.00 Very Low Very Low Very Low
Adhesions 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To verify that HA affects breast cancer cell behavior in a clinically relevant manner we evaluated IL-8 secretion in site-specific metastatic populations of MDA-MB231.
Localization (secretion) of MDA-MB231 associated with breast cancer
1) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809751 Disease Relevance 0.56 Pain Relevance 0
While VEGF and IL-11 secretion by MDA-MB231 cells were not affected by the scaffold type (Fig. 5A) and PTHrP was secreted at undetectable levels (<0.3 pM) from either mineralized or non-mineralized tumor models (data not shown), IL-8 secretion was increased by 38% in mineralized scaffolds HA (Fig 5A).
Localization (secretion) of MDA-MB231 associated with cancer
2) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809751 Disease Relevance 0.55 Pain Relevance 0
For the reversibility study, both MCF-7 and MDA-MB-231 BrCa cells were treated exactly as described above except, after synchronization of cell cycle they were incubated with 375 ?
Localization (treated) of MDA-MB-231 in MDA-MB-231 associated with breast cancer
3) Confidence 0.01 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2730474 Disease Relevance 0.48 Pain Relevance 0
For the reversibility study, both MCF-7 and MDA-MB-231 BrCa cells were treated exactly as described above except, after synchronization of cell cycle they were incubated with 375 ?
Localization (treated) of MDA-MB-231 in MCF-7 associated with breast cancer
4) Confidence 0.00 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2730474 Disease Relevance 0.48 Pain Relevance 0

General Comments

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