INT279815

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Context Info
Confidence 0.43
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.67
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn9a) transmembrane transport (Scn9a)
Anatomy Link Frequency
ACN 2
Scn9a (Mus musculus)
Pain Link Frequency Relevance Heat
Electroencephalography 1 66.00 Quite High
Nav1.7 10 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
Paroxysmal extreme pain disorder 7 5.00 Very Low Very Low Very Low
primary erythermalgia 5 5.00 Very Low Very Low Very Low
sodium channel 4 5.00 Very Low Very Low Very Low
anticonvulsant 3 5.00 Very Low Very Low Very Low
Migraine 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Convulsion 72 93.00 High High
Febrile Convulsions 60 76.44 Quite High
Syncope 2 55.84 Quite High
Absence Epilepsy 1 51.76 Quite High
Epilepsy 22 50.00 Quite Low
Sclerosis 1 37.60 Quite Low
Partial Seizures 7 35.44 Quite Low
Death 1 35.36 Quite Low
Syndrome 46 5.00 Very Low Very Low Very Low
Disease 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Briefly, the following changes were introduced into the wild-type Scn9a (Figure 2A): the p.N641Y mutation into exon 11, the ACN positive selection vector into intron 10, and the negative TK selection vector into intron 12 (Figure 2B).
Positive_regulation (negative) of Neg (negative) Gene_expression (introduced) of Scn9a in ACN
1) Confidence 0.43 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730533 Disease Relevance 0.67 Pain Relevance 0.03

General Comments

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