INT279821

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Context Info
Confidence 0.44
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.79
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn9a) transmembrane transport (Scn9a)
Scn9a (Mus musculus)
Pain Link Frequency Relevance Heat
Nav1.7 57 99.92 Very High Very High Very High
Pain 53 99.52 Very High Very High Very High
sodium channel 21 99.38 Very High Very High Very High
Paroxysmal pain 1 97.72 Very High Very High Very High
addiction 5 67.76 Quite High
burning pain 1 46.00 Quite Low
dorsal root ganglion 1 23.84 Low Low
potassium channel 3 21.36 Low Low
Paroxysmal extreme pain disorder 7 5.00 Very Low Very Low Very Low
Action potential 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 16 99.98 Very High Very High Very High
Pain 55 99.52 Very High Very High Very High
Febrile Convulsions 63 98.96 Very High Very High Very High
Convulsion 73 89.84 High High
Targeted Disruption 3 88.96 High High
Epilepsy 22 84.72 Quite High
Syndrome 46 71.36 Quite High
Somatoform Disorder 17 63.76 Quite High
Erythermalgia 17 62.36 Quite High
Myoclonic Epilepsies 2 58.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a genomic region on human chromosome 2 known to harbor the febrile seizure SCN1A sodium channel gene, we now report a disease-causing mutation in the adjacent gene, SCN9A (Nav1.7), in a large family with febrile seizures.
Regulation (causing) of SCN9A associated with sodium channel, febrile convulsions, disease and nav1.7
1) Confidence 0.44 Published 2009 Journal PLoS Genetics Section Abstract Doc Link PMC2730533 Disease Relevance 1.72 Pain Relevance 0.27
Here we report for the first time missense mutations in SCN9A that cause CIP and demonstrate that the amino acid changes result in loss of function of Nav 1.7.


Regulation (missense) of SCN9A associated with pain
2) Confidence 0.41 Published 2010 Journal Human Mutation Section Body Doc Link PMC2966863 Disease Relevance 1.07 Pain Relevance 0.56

General Comments

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