INT279822

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.65
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.73
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn2a1)
Anatomy Link Frequency
brain 1
Scn2a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nav1.2 18 100.00 Very High Very High Very High
Nav1.6 24 99.36 Very High Very High Very High
sodium channel 10 98.64 Very High Very High Very High
anticonvulsant 3 28.88 Quite Low
Nav1.7 10 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
tetrodotoxin 8 5.00 Very Low Very Low Very Low
Paroxysmal extreme pain disorder 7 5.00 Very Low Very Low Very Low
primary erythermalgia 5 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Convulsion 72 96.76 Very High Very High Very High
Syndrome 46 95.60 Very High Very High Very High
Febrile Convulsions 60 92.52 High High
Ganglion Cysts 42 92.16 High High
Epilepsy 22 88.08 High High
Partial Seizures 7 67.92 Quite High
Post-traumatic Epilepsy 1 60.32 Quite High
Status Epilepticus 2 54.52 Quite High
Disease 15 40.24 Quite Low
Myoclonic Epilepsies 2 34.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both models started with identical K channel densities and kinetics, but one contained Nav1.2 channels, and the other Nav1.6 channels.
Gene_expression (channels) of Nav1.2 associated with nav1.2 and nav1.6
1) Confidence 0.65 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2924322 Disease Relevance 0 Pain Relevance 1.14
Recent immunocytochemical evidence shows that Nav1.2 channels are initially expressed at the thin segment during early development but later replaced by Nav1.6 channels [52].
Gene_expression (expressed) of Nav1.2 associated with nav1.2 and nav1.6
2) Confidence 0.58 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2924322 Disease Relevance 0.09 Pain Relevance 0.66
subunit genes including SCN1A, SCN2A and SCN3A that share over 85% identity and are highly expressed in brain [15].
Gene_expression (ly expres) of SCN2A in brain
3) Confidence 0.49 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730533 Disease Relevance 1.64 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox