INT279846

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Context Info
Confidence 0.68
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 42
Disease Relevance 11.10
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nipbl) cell cycle (Nipbl)
Anatomy Link Frequency
bars 1
embryonic stage 1
fat 1
corpus callosum 1
MEFs 1
Nipbl (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 210 98.36 Very High Very High Very High
alcohol 42 89.36 High High
agonist 42 75.24 Quite High
Inflammation 126 64.84 Quite High
Immobilon 42 47.80 Quite Low
Pain 42 33.32 Quite Low
cytokine 42 19.88 Low Low
Disease Link Frequency Relevance Heat
Syndrome 2940 98.48 Very High Very High Very High
Epidermal Cyst 42 97.12 Very High Very High Very High
Congenital Anomalies 966 96.20 Very High Very High Very High
Heart Defects 126 95.00 High High
Lifespan 42 92.72 High High
Disease 168 92.00 High High
Body Weight 42 90.20 High High
Keloid Scars 42 89.52 High High
Cognitive Disorder 42 88.96 High High
Corneal Opacity 42 87.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of the 80 genes (not counting Nipbl itself) with significant differential expression in Nipbl+/?
Gene_expression (expression) of Nipbl
1) Confidence 0.68 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.19 Pain Relevance 0.03
A more revealing analysis of the data can be obtained by correlating Pcdhb transcript levels in each tissue sample, regardless of genotype, against Nipbl transcript levels within that sample (i.e. treating Nipbl expression as a quantitative trait; Figure 8C, Figure S4).
Gene_expression (expression) of Nipbl
2) Confidence 0.68 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0 Pain Relevance 0
Of the 80 genes (not counting Nipbl itself) with significant differential expression in Nipbl+/?
Gene_expression (expression) of Nipbl
3) Confidence 0.68 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.14 Pain Relevance 0.03
More importantly, the degree of decrease in Nipbl expression in Nipbl+/?
Gene_expression (expression) of Nipbl
4) Confidence 0.68 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.25 Pain Relevance 0
This approach offers greater discriminatory power because Nipbl expression in individual samples varies significantly, even within mutant and wildtype groups, and occasionally overlaps between the two groups.
Gene_expression (expression) of Nipbl
5) Confidence 0.68 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0 Pain Relevance 0
Interestingly, in Drosophila, inhibition of Nipped-B expression also leads to up-regulation of the ortholog of Stag1 [31].
Gene_expression (expression) of Nipped-B
6) Confidence 0.67 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.09 Pain Relevance 0
When western blotting was used to quantify levels of NIPBL protein in Nipbl+/?
Gene_expression (levels) of NIPBL protein
7) Confidence 0.67 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0 Pain Relevance 0.03
The RRS564 allele is hereafter referred to as Nipbl564 and mice heterozygous for this allele as Nipbl+/?
Gene_expression (heterozygous) of Nipbl564
8) Confidence 0.67 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0 Pain Relevance 0
In Drosophila, for example, changes in levels of Nipped-B or cohesin structural components alter the expression of developmental regulator genes, such as homeodomain transcription factors [30]–[33].
Gene_expression (expression) of Nipped-B
9) Confidence 0.67 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.64 Pain Relevance 0
Indeed, the results of the analysis indicate that Pcdhb expression correlates strongly with Nipbl transcript level, lending support to the view that Pcdhb transcription is directly affected by the amount of NIPBL present in cells.
Gene_expression (present) of NIPBL
10) Confidence 0.59 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.05 Pain Relevance 0
These phenotypes arose despite a decrease in Nipbl transcript levels of only ?
Gene_expression (transcript) of Nipbl
11) Confidence 0.59 Published 2009 Journal PLoS Genetics Section Abstract Doc Link PMC2730539 Disease Relevance 0.61 Pain Relevance 0
The RRS564 allele is hereafter referred to as Nipbl564 and mice heterozygous for this allele as Nipbl+/?
Gene_expression (/) of Nipbl
12) Confidence 0.59 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0 Pain Relevance 0
In cultured Nipbl+/?
Gene_expression (/) of Nipbl
13) Confidence 0.59 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0 Pain Relevance 0
As shown in Figure 8B, the data support the microarray results from the earlier embryonic stage, and indicate that most transcriptional changes in Nipbl+/?
Gene_expression (/) of Nipbl in embryonic stage
14) Confidence 0.59 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0 Pain Relevance 0
We favor the former explanation because, in both Drosophila and man, the evidence indicates that null mutation of a single allele of Nipped-B/NIPBL produces only a 25–30% drop in transcript levels, the same decrease we observe in Nipbl+/?
Gene_expression (/) of Nipbl
15) Confidence 0.59 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.21 Pain Relevance 0
Despite these differences, it is clear that the Nipbl+/?
Gene_expression (/) of Nipbl
16) Confidence 0.59 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 1.14 Pain Relevance 0
Four wildtype and five Nipbl+/?
Gene_expression (/) of Nipbl
17) Confidence 0.59 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0 Pain Relevance 0
Abnormal heart and bone development, and reduced growth in Nipbl+/?
Gene_expression (growth) of Nipbl in heart
18) Confidence 0.59 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.39 Pain Relevance 0
We favor the former explanation because, in both Drosophila and man, the evidence indicates that null mutation of a single allele of Nipped-B/NIPBL produces only a 25–30% drop in transcript levels, the same decrease we observe in Nipbl+/?
Gene_expression (allele) of NIPBL
19) Confidence 0.59 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.14 Pain Relevance 0
These observations suggest that, in addition to being intrinsically small, Nipbl+/?
Gene_expression (/) of Nipbl
20) Confidence 0.59 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.38 Pain Relevance 0

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