INT279847

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Context Info
Confidence 0.28
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.82
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Cebpb) nucleus (Cebpb) DNA binding (Cebpb)
transcription factor binding (Cebpb) cytoplasm (Cebpb)
Anatomy Link Frequency
macrophages 1
heart 1
Cebpb (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 48 94.20 High High
cytokine 21 81.68 Quite High
chemokine 12 80.56 Quite High
Inflammation 55 59.84 Quite High
Inflammatory mediators 4 58.36 Quite High
Arthritis 20 51.52 Quite High
rheumatoid arthritis 8 26.24 Quite Low
medulla 5 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 40 100.00 Very High Very High Very High
Congenital Anomalies 23 98.44 Very High Very High Very High
Heart Defects 3 98.04 Very High Very High Very High
Craniofacial Abnormalities 2 97.02 Very High Very High Very High
Convulsion 4 96.60 Very High Very High Very High
INFLAMMATION 111 94.20 High High
Syndrome 70 91.84 High High
Targeted Disruption 8 86.40 High High
Acute-phase Reaction 8 75.44 Quite High
Infection 5 60.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These include skeletal and craniofacial abnormalities (Lpar1, Pitx2, Satb2, Tcof1, Trps1); heart defects (Adm, Cited2, Cxcl12, Gja1, Hey2, Pitx2, Mef2c); reduced body size (Ebf1, Lpar1, Hsd3b7, Mef2c); decreased adiposity (Cebpb, Ebf1, Lpar1, Npy, Vldlr); behavioral abnormalities (Avpr1a, Ctnnd2, Lpar1, Vldlr); seizures (Cdk5r1, Gabrb1, Gabrb2, Neto1, Nr4a3, Plcb1, S100b, Sv2b); and hearing deficits (Cldn11, Eya, Gjb2, Gjb6) [66], [92]–[124].
Negative_regulation (decreased) of Cebpb in heart associated with convulsion, congenital anomalies, heart defects and craniofacial abnormalities
1) Confidence 0.28 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.60 Pain Relevance 0
Transient transfection of a precursor miR-155 (pre-miR-155) at 5-nM concentration into mouse Raw264.7 macrophages resulted in significant repression of the c/ebp Beta isoforms LIP and LAP, whereas concomitant transfection with equimolar LNA-antimiR into the cells effectively antagonized the miR-155-mediated c/ebp Beta repression compared to the LNA control transfected cells (Figure 2C).
Negative_regulation (repression) of isoforms LIP in macrophages associated with repression
2) Confidence 0.17 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 0.33 Pain Relevance 0
Systemically delivered LNA-antimiR compound derepresses the LIP isoform of c/ebp Beta compared to both saline- and LNA control-treated mice (**P < 0.01).
Negative_regulation (derepresses) of LIP isoform
3) Confidence 0.17 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 0.09 Pain Relevance 0.08
This resulted in significant derepression of both the LAP and LIP isoforms in comparison to the vehicle-treated control mice (Figure 4C), which is consistent with the notion that miR-155 negatively regulates c/ebp Beta proteins in vivo in mouse splenocytes during acute inflammatory response.
Negative_regulation (derepression) of LIP associated with inflammatory response
4) Confidence 0.14 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 0.09 Pain Relevance 0.05
Notably, we show for the first time that silencing of miR-155 by intravenously injected LNA-antimiR in LPS-treated mice results in marked derepression of the LAP and LIP isoforms of c/ebp Beta in mouse splenocytes, indicating that miR-155 acts as an important negative regulator of c/ebp Beta in vivo during acute inflammatory response.
Negative_regulation (derepression) of LIP associated with inflammatory response
5) Confidence 0.06 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 0.71 Pain Relevance 0.31

General Comments

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