INT279853

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Context Info
Confidence 0.51
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 2.37
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nipbl) cell cycle (Nipbl)
Anatomy Link Frequency
heart 2
Nipbl (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 55 98.36 Very High Very High Very High
Inflammation 33 64.84 Quite High
alcohol 11 6.08 Low Low
cytokine 11 5.00 Very Low Very Low Very Low
agonist 11 5.00 Very Low Very Low Very Low
Immobilon 11 5.00 Very Low Very Low Very Low
Pain 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Epidermal Cyst 11 97.32 Very High Very High Very High
Syndrome 770 96.48 Very High Very High Very High
Lifespan 11 92.72 High High
Congenital Anomalies 253 88.80 High High
Cardiovascular Disorder Under Development 22 74.36 Quite High
Heart Defects 33 70.00 Quite High
Deafness 11 67.84 Quite High
Disorders Of The Lacrimal System 22 66.08 Quite High
Infection 11 65.36 Quite High
INFLAMMATION 33 64.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
More importantly, the degree of decrease in Nipbl expression in Nipbl+/?
Negative_regulation (decrease) of Gene_expression (expression) of Nipbl
1) Confidence 0.51 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.25 Pain Relevance 0
The RRS564 allele is hereafter referred to as Nipbl564 and mice heterozygous for this allele as Nipbl+/?
Negative_regulation (referred) of Gene_expression (heterozygous) of Nipbl564
2) Confidence 0.43 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0 Pain Relevance 0
Interestingly, in Drosophila, inhibition of Nipped-B expression also leads to up-regulation of the ortholog of Stag1 [31].
Negative_regulation (inhibition) of Gene_expression (expression) of Nipped-B
3) Confidence 0.43 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.09 Pain Relevance 0
Levels of Nipbl expression are reduced by only 25–30% in Nipbl+/?
Negative_regulation (reduced) of Gene_expression (expression) of Nipbl
4) Confidence 0.38 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.77 Pain Relevance 0.15
Most Nipbl+/?
Negative_regulation (Most) of Gene_expression (/) of Nipbl
5) Confidence 0.37 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.42 Pain Relevance 0.05
As shown in Table 1, when the Nipbl+/?
Negative_regulation (shown) of Gene_expression (/) of Nipbl
6) Confidence 0.37 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.05 Pain Relevance 0
This approach offers greater discriminatory power because Nipbl expression in individual samples varies significantly, even within mutant and wildtype groups, and occasionally overlaps between the two groups.
Negative_regulation (overlaps) of Gene_expression (expression) of Nipbl
7) Confidence 0.37 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0 Pain Relevance 0
In cultured Nipbl+/?
Negative_regulation (cultured) of Gene_expression (/) of Nipbl
8) Confidence 0.37 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0 Pain Relevance 0
In view of these data, it was decided that further analysis of the Nipbl?
Negative_regulation (decided) of Gene_expression (analysis) of Nipbl
9) Confidence 0.37 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.16 Pain Relevance 0
More importantly, the degree of decrease in Nipbl expression in Nipbl+/?
Negative_regulation (degree) of Gene_expression (expression) of Nipbl
10) Confidence 0.37 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.25 Pain Relevance 0
Abnormal heart and bone development, and reduced growth in Nipbl+/?
Negative_regulation (reduced) of Gene_expression (growth) of Nipbl in heart
11) Confidence 0.37 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.39 Pain Relevance 0

General Comments

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