INT279862

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Context Info
Confidence 0.36
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.22
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nipbl) cell cycle (Nipbl)
Nipbl (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 25 76.76 Quite High
Inflammation 15 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
Immobilon 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 350 90.64 High High
Lifespan 5 84.52 Quite High
Failure To Thrive 5 83.04 Quite High
Epidermal Cyst 5 77.40 Quite High
Death 5 74.48 Quite High
Congenital Anomalies 115 68.44 Quite High
Cardiovascular Disorder Under Development 10 54.44 Quite High
Ectromelia 5 37.56 Quite Low
Heart Defects 15 26.72 Quite Low
Atrial Heart Septal Defects 5 26.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies using Drosophila cell lines have demonstrated that cohesin and Nipped-B binding are concentrated near the promoters of active transcriptional units [34].
Nipped-B Binding (binding) of
1) Confidence 0.36 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.29 Pain Relevance 0
These observations suggest that cohesin and NIPBL may interact in multiple ways with the transcriptional machinery.
NIPBL Binding (interact) of
2) Confidence 0.36 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.22 Pain Relevance 0
To investigate early postnatal growth of Nipbl+/?
Nipbl Binding (growth) of
3) Confidence 0.33 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.44 Pain Relevance 0.04
To determine whether lethality occurs in utero, we examined litters for Nipbl+/?
Nipbl Spec (examined) Binding (litters) of
4) Confidence 0.33 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.05 Pain Relevance 0
Recently, NIPBL has also been shown to bind and recruit histone deacetylases to chromatin [38].
NIPBL Binding (bind) of
5) Confidence 0.31 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.21 Pain Relevance 0

General Comments

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