INT279867

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.81
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (Rec8) chromosome segregation (Rec8) chromosome (Rec8)
nucleus (Rec8)
Rec8 (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 15 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Immobilon 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 210 90.64 High High
Congenital Anomalies 69 61.60 Quite High
Ectromelia 3 38.04 Quite Low
Obesity 15 5.00 Very Low Very Low Very Low
Convulsion 12 5.00 Very Low Very Low Very Low
Disease 12 5.00 Very Low Very Low Very Low
Ventricular Heart Septal Defects 9 5.00 Very Low Very Low Very Low
Heart Defects 9 5.00 Very Low Very Low Very Low
INFLAMMATION 9 5.00 Very Low Very Low Very Low
Disorders Of The Lacrimal System 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These observations suggest that cohesin and NIPBL may interact in multiple ways with the transcriptional machinery.
cohesin Binding (interact) of
1) Confidence 0.01 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.22 Pain Relevance 0
Studies using Drosophila cell lines have demonstrated that cohesin and Nipped-B binding are concentrated near the promoters of active transcriptional units [34].
cohesin Binding (binding) of
2) Confidence 0.01 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.30 Pain Relevance 0
In mammalian cells, cohesin often binds, in an NIPBL-dependent manner, to sites occupied by the transcriptional insulator protein CTCF, where it plays a significant role in CTCF function [35]–[37].
cohesin Binding (binds) of
3) Confidence 0.01 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.29 Pain Relevance 0

General Comments

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