INT279869

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Context Info
Confidence 0.43
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 4.30
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nipbl) cell cycle (Nipbl)
Anatomy Link Frequency
liver 1
Nipbl (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 7 59.08 Quite High
medulla 35 5.00 Very Low Very Low Very Low
Inflammation 21 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
Immobilon 7 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
alcohol 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 161 98.32 Very High Very High Very High
Syndrome 490 97.64 Very High Very High Very High
Heart Defects 21 92.56 High High
Cognitive Disorder 7 89.88 High High
Disease 28 88.28 High High
Craniofacial Abnormalities 14 75.68 Quite High
Obesity 35 71.32 Quite High
Keloid Scars 7 63.24 Quite High
Corneal Opacity 7 61.44 Quite High
Ventricular Heart Septal Defects 21 56.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because such mice display pervasive developmental abnormalities, transcriptome data can be expected to reflect not only the direct consequences of reduced Nipbl function, but also a potentially large number of transcriptional effects that are secondary consequences of abnormal morphology and physiology.
Negative_regulation (reduced) of Nipbl associated with congenital anomalies
1) Confidence 0.43 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.28 Pain Relevance 0
It is fascinating that the diverse and severe pathology observed in this study is caused by only a 25–35% decrease in the level of Nipbl transcripts (Figure 5; also see Table S2 and Table S3).
Negative_regulation (decrease) of Nipbl
2) Confidence 0.43 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.87 Pain Relevance 0
Gene expression profiling demonstrated that Nipbl deficiency leads to modest but significant transcriptional dysregulation of many genes.
Negative_regulation (deficiency) of Nipbl
3) Confidence 0.43 Published 2009 Journal PLoS Genetics Section Abstract Doc Link PMC2730539 Disease Relevance 0.81 Pain Relevance 0
These phenotypes remained stable through many generations of outcrossing, and occurred in the context of modest (25–35%) reductions in levels of Nipbl mRNA in every tissue measured (embryonic brain, MEFs, adult liver).
Negative_regulation (reductions) of Nipbl in liver
4) Confidence 0.43 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.60 Pain Relevance 0
How reduction of NIPBL function gives rise to pervasive developmental defects in CdLS is not understood, so a model of CdLS was developed by generating mice that carry one null allele of Nipbl.
Negative_regulation (reduction) of NIPBL associated with syndrome
5) Confidence 0.38 Published 2009 Journal PLoS Genetics Section Abstract Doc Link PMC2730539 Disease Relevance 1.04 Pain Relevance 0
These phenotypes arose despite a decrease in Nipbl transcript levels of only ?
Negative_regulation (decrease) of Nipbl
6) Confidence 0.38 Published 2009 Journal PLoS Genetics Section Abstract Doc Link PMC2730539 Disease Relevance 0.56 Pain Relevance 0
MEFs (Table S3), 20% (16/80) are also found among the 978 genes whose expression was altered in Nipbl+/?
Negative_regulation (altered) of Nipbl
7) Confidence 0.37 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.13 Pain Relevance 0.03

General Comments

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