INT27988

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Context Info
Confidence 0.42
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 5.71
Pain Relevance 2.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (AGT) small molecule metabolic process (AGT) aging (AGT)
extracellular region (AGT) extracellular matrix organization (AGT) cell-cell signaling (AGT)
Anatomy Link Frequency
blood 4
kidney 4
plasma 2
superior 2
heart 2
AGT (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 1 100.00 Very High Very High Very High
agonist 10 96.52 Very High Very High Very High
Calcium channel 27 94.76 High High
bradykinin 8 94.32 High High
antagonist 44 92.32 High High
substance P 1 91.92 High High
Enkephalin 1 90.88 High High
aspirin 6 86.88 High High
Angina 13 86.64 High High
cINOD 49 83.48 Quite High
Disease Link Frequency Relevance Heat
Hypertension 85 100.00 Very High Very High Very High
Heart Rate Under Development 23 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 6 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 17 99.80 Very High Very High Very High
Natriuresis 14 98.48 Very High Very High Very High
Pressure And Volume Under Development 19 97.60 Very High Very High Very High
Colon Cancer 15 93.44 High High
Cv General 3 Under Development 13 86.64 High High
Hypotension 14 86.56 High High
INFLAMMATION 28 83.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, because only activation of the alpha(2)-adrenergic receptors appears responsible for somnolence, the imidazoline-receptor agonists moxonidine and rilmenidine, both relatively selective for I-receptors, may have superior clinical utility in antihypertensive therapy, since they are sympatholytic and also suppress the generation of angiotensin II.
Negative_regulation (suppress) of Positive_regulation (generation) of angiotensin II in superior associated with agonist
1) Confidence 0.42 Published 1996 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 8872295 Disease Relevance 0.09 Pain Relevance 0.34
Indomethacin reduced base-line and diuretic-induced increase in plasma renin activity, plasma angiotensin II levels and urinary excretion of prostaglandin 6-keto F1 alpha to a similar extent under the two sodium diets.
Negative_regulation (reduced) of Positive_regulation (increase) of angiotensin II in plasma
2) Confidence 0.36 Published 1989 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2703968 Disease Relevance 0.97 Pain Relevance 0.28
Both drugs caused a decrease in angiotensin (Ang) II level, an increase in Ang I level, and reduction in Ang II/Ang I ratio in arterial and coronary sinus blood.
Negative_regulation (decrease) of Positive_regulation (increase) of angiotensin in blood
3) Confidence 0.13 Published 2003 Journal Hypertension Section Abstract Doc Link 12623947 Disease Relevance 0.09 Pain Relevance 0.31
In the isolated perfused rabbit kidney, indomethacin inhibited the basal efflux of all fatty acids as well as the angiotensin II--induced selective release off arachidonate.
Negative_regulation (inhibited) of Positive_regulation (--induced) of angiotensin II in kidney
4) Confidence 0.09 Published 1980 Journal Prostaglandins Section Abstract Doc Link 7465862 Disease Relevance 0.08 Pain Relevance 0.28
Secondly, telmisartan selectively blocks only the AT1 receptor and not the AT2 receptors and thus the actions of angiotensin II that are mediated through AT2 receptors are not blocked.
Negative_regulation (blocked) of Positive_regulation (mediated) of angiotensin II
5) Confidence 0.08 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2937316 Disease Relevance 0.35 Pain Relevance 0.05
Precautions for angiotensin II receptor blocker use in patients with renovascular hypertension, hypovolemia, and severe heart failure are the same as those for ACE inhibitors.
Negative_regulation (inhibitors) of Positive_regulation (Precautions) of angiotensin II in heart associated with heart rate under development, pressure volume 2 under development and hypertension
6) Confidence 0.07 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 1.13 Pain Relevance 0.10
M, indomethacin did not inhibit AA release from perfused rabbit kidney after a 1 h incubation, but did inhibit its rate of release after incubation with angiotensin II [16].
Negative_regulation (inhibit) of Positive_regulation (incubation) of angiotensin II in kidney
7) Confidence 0.05 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1458335 Disease Relevance 0.52 Pain Relevance 0.23
Angiotensin II receptor blockers impede the activation of angiotensin II AT1 receptors, preventing the vasoconstriction induced by angiotensin II, while blockade of the receptor in the renal cells helps prevent the renal retention of sodium.
Negative_regulation (impede) of Positive_regulation (activation) of angiotensin II associated with increased venous pressure under development
8) Confidence 0.02 Published 2010 Journal Patient Prefer Adherence Section Body Doc Link PMC2875720 Disease Relevance 0.54 Pain Relevance 0.12
Angiotensin II receptor blockers impede the activation of angiotensin II AT1 receptors, preventing the vasoconstriction induced by angiotensin II, while blockade of the receptor in the renal cells helps prevent the renal retention of sodium.
Negative_regulation (preventing) of Positive_regulation (activation) of angiotensin II associated with increased venous pressure under development
9) Confidence 0.02 Published 2010 Journal Patient Prefer Adherence Section Body Doc Link PMC2875720 Disease Relevance 0.54 Pain Relevance 0.12
They block the activation of angiotensin II receptors via block of AT1 receptors, causing vasodilation, reduced of secretion of vasopressin, reduced production and secretion of aldosterone, and reduction of blood pressure.
Negative_regulation (block) of Positive_regulation (activation) of angiotensin II in blood associated with increased venous pressure under development
10) Confidence 0.02 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2920560 Disease Relevance 0.81 Pain Relevance 0.18
ACE inhibitors block the activity of the metalloproteinase ACE by binding to its active site, thus displacing angiotensin I and preventing its conversion to vasopressive angiotensin II.
Negative_regulation (block) of Positive_regulation (displacing) of angiotensin I associated with metalloproteinase
11) Confidence 0.02 Published 2001 Journal Acta Derm. Venereol. Section Abstract Doc Link 11800136 Disease Relevance 0.58 Pain Relevance 0.27

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