INT27989

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Context Info
Confidence 0.55
First Reported 1989
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 18
Total Number 20
Disease Relevance 12.69
Pain Relevance 2.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (REN) extracellular space (REN) extracellular region (REN)
intracellular (REN) response to stress (REN)
Anatomy Link Frequency
plasma 15
blood 5
Sympathetic 4
endothelial cells 2
REN (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 5 100.00 Very High Very High Very High
imagery 6 98.52 Very High Very High Very High
headache 5 96.32 Very High Very High Very High
Inflammation 8 94.56 High High
COX-2 inhibitor 9 93.28 High High
anesthesia 7 92.00 High High
epidural 2 91.56 High High
ischemia 10 90.00 High High
alcohol 10 86.40 High High
cINOD 4 77.84 Quite High
Disease Link Frequency Relevance Heat
Hypertension 151 99.92 Very High Very High Very High
Necrosis 6 99.84 Very High Very High Very High
Cancer 5 99.66 Very High Very High Very High
Polyuria 2 99.64 Very High Very High Very High
Hyperplasia 4 99.50 Very High Very High Very High
Increased Venous Pressure Under Development 42 99.16 Very High Very High Very High
Weight Loss 2 98.76 Very High Very High Very High
Shock 2 98.32 Very High Very High Very High
Syndrome 29 98.08 Very High Very High Very High
Left Ventricular Hypertrophy 10 98.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the one hand, an intact sympathetic nervous system prevents reduction in blood pressure immediately; on the other hand, sympathetic activation directly stimulates renin production; the result is diminished and elevated sodium retention respectively.
Positive_regulation (stimulates) of Gene_expression (production) of renin in blood
1) Confidence 0.55 Published 2010 Journal Diabetologia Section Body Doc Link PMC2910895 Disease Relevance 0.38 Pain Relevance 0
Sympathetic activation also directly stimulates renin production, which induces sodium retention.
Positive_regulation (stimulates) of Gene_expression (production) of renin in Sympathetic
2) Confidence 0.55 Published 2010 Journal Diabetologia Section Body Doc Link PMC2910895 Disease Relevance 0.66 Pain Relevance 0.03
The exercise-induced increases in heart rate; cardiac output; leg blood flow; plasma concentrations of growth hormone, adrenocorticotropin, cortisol, and catecholamines; renin activity; glucose production and disappearance; norepinephrine spillover [2, 190 +/- 341 ng/min (exercise at 11.5% O(2)) vs. 988 +/- 95 ng/min (exercise during normoxia)]; lactate release from and glucose uptake in the leg; and the decreases in plasma insulin and free fatty acids were exaggerated in hypoxia (P < 0.05).
Positive_regulation (increases) of Gene_expression (activity) of renin in plasma associated with hypoxia and catecholamine
3) Confidence 0.49 Published 1999 Journal Am. J. Physiol. Section Abstract Doc Link 10409260 Disease Relevance 0.53 Pain Relevance 0.19
In the group given Doxazocin, there was a significant increase in serum progesterone and ovarian renin angiotensin system soluble and membrane-bound enzymes confirming that alpha adrenergic receptors caused inhibition of progesterone release.
Positive_regulation (increase) of Gene_expression (enzymes) of renin
4) Confidence 0.49 Published 2008 Journal Cases J Section Body Doc Link PMC2481240 Disease Relevance 0.22 Pain Relevance 0.09
Indomethacin reduced base-line and diuretic-induced increase in plasma renin activity, plasma angiotensin II levels and urinary excretion of prostaglandin 6-keto F1 alpha to a similar extent under the two sodium diets.
Positive_regulation (increase) of Gene_expression (levels) of renin in plasma
5) Confidence 0.44 Published 1989 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2703968 Disease Relevance 0.96 Pain Relevance 0.28
Bartter's syndrome is a rare disorder characterized by normal or low arterial blood pressure (BP), despite marked elevation in plasma renin activity, angiotensin II (Ang-II), and aldosterone, along with hypokalemic metabolic alkalosis.
Positive_regulation (elevation) of in plasma Gene_expression (activity) of plasma renin in blood associated with alkalosis and syndrome
6) Confidence 0.42 Published 1993 Journal J Clin Anesth Section Abstract Doc Link 8373612 Disease Relevance 0.58 Pain Relevance 0.27
Sympathetic activation also directly stimulates renin production, which induces sodium retention.
Positive_regulation (induces) of Gene_expression (production) of renin in Sympathetic
7) Confidence 0.40 Published 2010 Journal Diabetologia Section Body Doc Link PMC2910895 Disease Relevance 0.66 Pain Relevance 0.03
Furthermore, aliskiren significantly reduced the adhesion of THP-1 (T-helper precursor) cells to tumor necrosis factor-alpha-activated human umbilical vein endothelial cells and blunted tumor necrosis factor-alphainduced renin and Ang II production in these cells.
Positive_regulation (alphainduced) of Gene_expression (production) of renin in endothelial cells associated with necrosis, cancer and adhesions
8) Confidence 0.39 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2952455 Disease Relevance 1.32 Pain Relevance 0.12
Isoflurane markedly increased the plasma levels of renin and aldosterone, whereas vasopressin was mostly unchanged.
Positive_regulation (increased) of Gene_expression (levels) of renin in plasma
9) Confidence 0.37 Published 2007 Journal Anesthesiology Section Body Doc Link 17585212 Disease Relevance 0 Pain Relevance 0
The systemic consequence of vasodilatation is reduction of blood pressure (bottom), leading to renin production and sodium retention.
Positive_regulation (leading) of Gene_expression (production) of renin in blood associated with increased venous pressure under development
10) Confidence 0.37 Published 2010 Journal Diabetologia Section Body Doc Link PMC2910895 Disease Relevance 0.50 Pain Relevance 0
These experiments were conducted to examine the effects of prostaglandin synthesis inhibitors on basal and isoproterenol-induced plasma renin concentration and renin gene expression in the late-gestation fetal lamb.
Spec (examine) Positive_regulation (isoproterenol-induced) of Gene_expression (expression) of renin gene in plasma
11) Confidence 0.34 Published 2003 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 12456386 Disease Relevance 0 Pain Relevance 0.11
These experiments were conducted to examine the effects of prostaglandin synthesis inhibitors on basal and isoproterenol-induced plasma renin concentration and renin gene expression in the late-gestation fetal lamb.
Spec (examine) Positive_regulation (isoproterenol-induced) of Gene_expression (expression) of plasma renin in plasma
12) Confidence 0.34 Published 2003 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 12456386 Disease Relevance 0 Pain Relevance 0.11
Acute worsening of chronic hyponatremia may have various etiologic factors, including: generalized haemodynamic derangement with low peripheral resistance, reduced effective arterial volume, hypothalamic overproduction of antidiuretic hormone, elevated renin and angiotensin, hypotonic fluid ingestion and reduced glomerular filtration, all of which may lead to marked water retention [5,7,8].
Positive_regulation (elevated) of Gene_expression (overproduction) of renin associated with hyponatremia and pressure and volume under development
13) Confidence 0.32 Published 2010 Journal Cases J Section Body Doc Link PMC2851673 Disease Relevance 1.38 Pain Relevance 0.04
Renal cortical cells in culture from animals receiving only saline exhibited increased levels of renin mRNA when treated with isoproterenol, forskolin, or IBMX.
Positive_regulation (increased) of Gene_expression (levels) of renin mRNA
14) Confidence 0.31 Published 2003 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 12456386 Disease Relevance 0 Pain Relevance 0.21
Plasma renin levels, measured in 20 patients, were elevated in most cases and correlated inversely (r=-0.63, P<0.01) with the plasma sodium concentration.
Positive_regulation (elevated) of Gene_expression (levels) of renin in plasma
15) Confidence 0.31 Published 1999 Journal Hypertension Section Abstract Doc Link 10205241 Disease Relevance 1.39 Pain Relevance 0.21
peripheral renin activity (PRA)
Positive_regulation (peripheral) of Gene_expression (activity) of renin
16) Confidence 0.11 Published 2004 Journal BMC Nephrol Section Body Doc Link PMC420241 Disease Relevance 1.89 Pain Relevance 0.17
Our findings are consistent with the renin hypothesis, which suggests that patients’ blood pressure response to different antihypertensive drugs depends on their plasma renin levels.25
Positive_regulation (depends) of Gene_expression (levels.25) of renin in plasma
17) Confidence 0.05 Published 2010 Journal BMJ : British Medical Journal Section Body Doc Link PMC2811239 Disease Relevance 0.14 Pain Relevance 0.03
According to the renin hypothesis, those patients receiving an additional anti-renin-system drug—such as an angiotensin converting enzyme inhibitor, an angiotensin receptor blocker, or a ?
Positive_regulation (as) of Gene_expression (hypothesis) of renin
18) Confidence 0.05 Published 2010 Journal BMJ : British Medical Journal Section Body Doc Link PMC2811239 Disease Relevance 0.25 Pain Relevance 0.06
According to the renin hypothesis, those patients receiving an additional anti-renin-system drug—such as an angiotensin converting enzyme inhibitor, an angiotensin receptor blocker, or a ?
Positive_regulation (According) of Gene_expression (hypothesis) of renin
19) Confidence 0.05 Published 2010 Journal BMJ : British Medical Journal Section Body Doc Link PMC2811239 Disease Relevance 0.25 Pain Relevance 0.04
JGA hyperplasia, a histologic sequel of increased renin production can be observed microscopically (Figure 4).
Positive_regulation (increased) of Gene_expression (production) of renin associated with hyperplasia
20) Confidence 0.04 Published 2010 Journal International Journal of Rheumatology Section Body Doc Link PMC2958499 Disease Relevance 1.58 Pain Relevance 0.11

General Comments

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