INT279894

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Context Info
Confidence 0.11
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.52
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (USF1, TGS1) cytosol (TGS1) nucleoplasm (TGS1)
small molecule metabolic process (TGS1) methyltransferase activity (TGS1) enzyme binding (USF1)
USF1 (Homo sapiens)
TGS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Combined Hyperlipidemia 508 100.00 Very High Very High Very High
Disease 48 67.60 Quite High
Dyslipidemia /

Combined Dyslipidemia

20 67.44 Quite High
Disorder Of Lipid Metabolism 60 62.80 Quite High
Hyperlipidemia 20 34.96 Quite Low
Obesity 32 26.48 Quite Low
Coronary Artery Disease 8 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Myocardial Infarction 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The FCHL causal candidate gene fatty acid desaturase 3 (FADS3) was associated with TGs in a recent Caucasian genome-wide significant association study and we replicated this association in Mexican FCHL families.
FCHL Binding (associated) of TGs associated with familial combined hyperlipidemia
1) Confidence 0.11 Published 2009 Journal PLoS Genetics Section Abstract Doc Link PMC2730565 Disease Relevance 0.99 Pain Relevance 0
In an independent Mexican FCHL dataset we replicate the association for TGs with the previously associated genome-wide SNP.
FCHL Binding (association) of TGs associated with familial combined hyperlipidemia
2) Confidence 0.07 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.77 Pain Relevance 0
We hypothesized that because FADS3 expression was associated with FCHL, any variation affecting the expression of FADS3 could be associated with FCHL or an FCHL component trait, especially TGs.
FCHL Binding (associated) of TGs associated with familial combined hyperlipidemia
3) Confidence 0.07 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.98 Pain Relevance 0
To summarize, we identify two co-expression modules associated with TGs, the key component trait of FCHL.
FCHL Binding (associated) of TGs associated with familial combined hyperlipidemia
4) Confidence 0.07 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.72 Pain Relevance 0

General Comments

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