INT279909

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Context Info
Confidence 0.12
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 6.00
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TGS1) transport (FADS3) small molecule metabolic process (TGS1)
endoplasmic reticulum (FADS3) cytoplasm (TGS1) cytosol (TGS1)
FADS3 (Homo sapiens)
TGS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 6 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Combined Hyperlipidemia 762 100.00 Very High Very High Very High
Disease 72 89.04 High High
Disorder Of Lipid Metabolism 90 84.24 Quite High
Dyslipidemia /

Combined Dyslipidemia

30 66.36 Quite High
Obesity 48 36.56 Quite Low
Hyperlipidemia 30 34.96 Quite Low
Coronary Artery Disease 12 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low
Myocardial Infarction 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The FCHL causal candidate gene fatty acid desaturase 3 (FADS3) was associated with TGs in a recent Caucasian genome-wide significant association study and we replicated this association in Mexican FCHL families.
FADS3 Binding (associated) of TGs associated with familial combined hyperlipidemia
1) Confidence 0.12 Published 2009 Journal PLoS Genetics Section Abstract Doc Link PMC2730565 Disease Relevance 0.97 Pain Relevance 0
The FCHL causal candidate gene fatty acid desaturase 3 (FADS3) was associated with TGs in a recent Caucasian genome-wide significant association study and we replicated this association in Mexican FCHL families.
fatty acid desaturase 3 Binding (associated) of TGs associated with familial combined hyperlipidemia
2) Confidence 0.12 Published 2009 Journal PLoS Genetics Section Abstract Doc Link PMC2730565 Disease Relevance 0.98 Pain Relevance 0
Interestingly, variation from the FADS1-2-3 genomic region was previously associated with TGs in a recent meta-analysis of GWAS in Caucasians [38].
FADS1-2-3 Binding (associated) of TGs
3) Confidence 0.09 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 1.08 Pain Relevance 0
One of the causal genes for FCHL, FADS3, coincides with a previous genome-wide significant association signal for TGs [38].
FADS3 Binding (association) of TGs associated with familial combined hyperlipidemia
4) Confidence 0.08 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.76 Pain Relevance 0
We hypothesized that because FADS3 expression was associated with FCHL, any variation affecting the expression of FADS3 could be associated with FCHL or an FCHL component trait, especially TGs.
FADS3 Binding (associated) of TGs associated with familial combined hyperlipidemia
5) Confidence 0.08 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.97 Pain Relevance 0
We chose to follow-up the SNP rs174547 residing in the FADS1-2-3 locus which was significantly associated with TGs at the genome-wide level in this previous meta-analysis [38].
FADS1-2-3 Binding (associated) of TGs
6) Confidence 0.08 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 1.11 Pain Relevance 0

General Comments

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