INT279937

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Context Info
Confidence 0.75
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 3
Disease Relevance 2.19
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (USF1) enzyme binding (USF1)
USF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Combined Hyperlipidemia 381 100.00 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

15 92.68 High High
Disease 36 68.16 Quite High
Hyperlipidemia 15 63.52 Quite High
Disorder Of Lipid Metabolism 45 28.28 Quite Low
Obesity 24 5.00 Very Low Very Low Very Low
Coronary Artery Disease 6 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Myocardial Infarction 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A Systems Genetics Approach Implicates USF1, FADS3, and Other Causal Candidate Genes for Familial Combined Hyperlipidemia

We hypothesized that a common SNP in the 3' untranslated region of the upstream transcription factor 1 (USF1), rs3737787, may affect lipid traits by influencing gene expression levels, and we investigated this possibility utilizing the Mexican population, which has a high predisposition to dyslipidemia.

Localization (region) of USF1 associated with familial combined hyperlipidemia
1) Confidence 0.75 Published 2009 Journal PLoS Genetics Section Title Doc Link PMC2730565 Disease Relevance 0.72 Pain Relevance 0
A Systems Genetics Approach Implicates USF1, FADS3, and Other Causal Candidate Genes for Familial Combined Hyperlipidemia

We hypothesized that a common SNP in the 3' untranslated region of the upstream transcription factor 1 (USF1), rs3737787, may affect lipid traits by influencing gene expression levels, and we investigated this possibility utilizing the Mexican population, which has a high predisposition to dyslipidemia.

Localization (region) of upstream transcription factor 1 associated with familial combined hyperlipidemia
2) Confidence 0.75 Published 2009 Journal PLoS Genetics Section Title Doc Link PMC2730565 Disease Relevance 0.72 Pain Relevance 0
1.16) (Table S3), supporting a link from rs3737787 to FCHL etiology.
Localization (etiology) of FCHL associated with familial combined hyperlipidemia
3) Confidence 0.65 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.56 Pain Relevance 0

General Comments

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