INT279940

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Context Info
Confidence 0.61
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 5.40
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (USF1) enzyme binding (USF1)
Anatomy Link Frequency
fat 1
edge 1
USF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 11 33.64 Quite Low
Inflammation 11 22.40 Low Low
Disease Link Frequency Relevance Heat
Familial Combined Hyperlipidemia 1397 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 165 91.08 High High
Disease 132 89.48 High High
Obesity 88 77.04 Quite High
Dyslipidemia /

Combined Dyslipidemia

55 75.44 Quite High
Hyperlipidemia 55 67.52 Quite High
Coronary Artery Disease 22 37.64 Quite Low
INFLAMMATION 11 22.40 Low Low
Myocardial Infarction 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The rs3737787 correlated genes had significant overlap both with i) the set of USF1 regulated genes identified in our USF1 over-expression experiment (n?
Regulation (regulated) of USF1
1) Confidence 0.61 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.26 Pain Relevance 0
To identify the causal SNP in USF1, additional functional studies are warranted that investigate allele-dependent effects of each of the three SNPs on USF1 isoform and protein levels.
Regulation (effects) of USF1
2) Confidence 0.45 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.48 Pain Relevance 0
This USF1-regulated FCHL-associated (URFA) module was enriched for genes involved in lipid metabolic processes.
Regulation (regulated) of FCHL associated with familial combined hyperlipidemia
3) Confidence 0.39 Published 2009 Journal PLoS Genetics Section Abstract Doc Link PMC2730565 Disease Relevance 0.89 Pain Relevance 0
Differential expression of genes based on the FCHL status was assayed by regressing FCHL status with the covariates age, sex and kinship on the expression of each gene.
Regulation (regressing) of FCHL associated with familial combined hyperlipidemia
4) Confidence 0.39 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.37 Pain Relevance 0
We hypothesized that if the SNP rs3737787 tagged LD bin alters the function of the transcription factor USF1, the effect could be assayed on the downstream expression of USF1 target genes, or the subsequent targets of those genes.
Regulation (alters) of USF1
5) Confidence 0.27 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.53 Pain Relevance 0
We hypothesized that rs3737787 affects the function of USF1, and that this effect could be identified as the differential expression of genes directly or indirectly regulated by USF1.
Regulation (affects) of USF1
6) Confidence 0.27 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.44 Pain Relevance 0
The direct targets of USF1 were previously identified using chromatin immunoprecipitation and high-resolution promoter microarrays (ChIP-Chip) [16].
Regulation (targets) of USF1
7) Confidence 0.27 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.45 Pain Relevance 0
To test this hypothesis we first identified the direct and indirect targets of USF1 by transiently over-expressing USF1 in vitro and assaying for differential expression using gene expression microarrays.
Regulation (targets) of USF1
8) Confidence 0.27 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.57 Pain Relevance 0
There was minimal relatedness between individuals, but to avoid confounding due to relatedness all analyses with the Mexican FCHL cases/controls were corrected for kinship.
Regulation (controls) of FCHL associated with familial combined hyperlipidemia
9) Confidence 0.24 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.33 Pain Relevance 0
Nevertheless, we consider that the identification of the URFA module in fat does further implicate a biological role of fat tissue in FCHL, although we cannot establish whether these FCHL modules are tissue-specific.
Regulation (role) of FCHL in fat associated with familial combined hyperlipidemia
10) Confidence 0.24 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.59 Pain Relevance 0
To evaluate whether the module causally affects FCHL component traits, we utilized the Network Edge Orienting (NEO) R software package [37] which takes SNP genotypes as input into structural equation models that compute causal edge orienting scores (referred to as LEO.NB scores).
Spec (whether) Regulation (affects) of FCHL in edge associated with familial combined hyperlipidemia
11) Confidence 0.24 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.36 Pain Relevance 0

General Comments

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