INT279944

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Context Info
Confidence 0.50
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 3.33
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (USF1) enzyme binding (USF1)
USF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 8 81.84 Quite High
Inflammation 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 96 96.60 Very High Very High Very High
Familial Combined Hyperlipidemia 1016 94.32 High High
Obesity 64 84.00 Quite High
Myocardial Infarction 8 20.00 Low Low
Coronary Artery Disease 16 18.40 Low Low
Disorder Of Lipid Metabolism 120 5.00 Very Low Very Low Very Low
Dyslipidemia /

Combined Dyslipidemia

40 5.00 Very Low Very Low Very Low
Hyperlipidemia 40 5.00 Very Low Very Low Very Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although our current study does not allow us to pinpoint which of these three USF1 SNPs in LD is the actual causative SNP, we were able to demonstrate that an allele-dependent effect of the rs3737787 tagged LD bin on downstream genes is mediated by USF1 and not the adjacent gene F11R.
Positive_regulation (causative) of Gene_expression (which) of USF1
1) Confidence 0.50 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.69 Pain Relevance 0
The transient transfection and over-expression of USF1 microarray data can be accessed in MIAME compliant format from NCBI GEO database (GSE17300).


Positive_regulation (accessed) of Gene_expression (expression) of USF1
2) Confidence 0.50 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.27 Pain Relevance 0.08
Transient transfection and over-expression of USF1 were conducted in HEK293T cells, which express the USF1 protein (Figure S1).
Positive_regulation (conducted) of Gene_expression (expression) of USF1
3) Confidence 0.50 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.64 Pain Relevance 0
Over-expression of USF1 was validated by western blot using Anti-HisG-HRP (Invitrogen, Cat No.
Positive_regulation (expression) of Gene_expression (expression) of USF1
4) Confidence 0.46 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.27 Pain Relevance 0
Over-expression of USF1 was validated by western blot (Figure S1).
Positive_regulation (-) of Gene_expression (expression) of USF1
5) Confidence 0.46 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.40 Pain Relevance 0
Over-expression of USF1 was validated by western blot (Figure S1).
Positive_regulation (expression) of Gene_expression (expression) of USF1
6) Confidence 0.46 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.40 Pain Relevance 0
Over-expression of USF1 was validated by western blot (Figure S1).
Positive_regulation (Over) of Gene_expression (expression) of USF1
7) Confidence 0.46 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.40 Pain Relevance 0
Over-expression of USF1 was validated by western blot using Anti-HisG-HRP (Invitrogen, Cat No.
Positive_regulation (Over) of Gene_expression (expression) of USF1
8) Confidence 0.46 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.27 Pain Relevance 0

General Comments

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