INT28

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Context Info
Confidence 0.62
First Reported 1976
Last Reported 2010
Negated 23
Speculated 7
Reported most in Abstract
Documents 106
Total Number 114
Disease Relevance 26.37
Pain Relevance 29.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gast) extracellular region (Gast)
Anatomy Link Frequency
plasma 13
stomach 6
neural 5
neurons 4
vagal nerves 2
Gast (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 198 100.00 Very High Very High Very High
Cholecystokinin 90 100.00 Very High Very High Very High
qutenza 37 100.00 Very High Very High Very High
anesthesia 27 100.00 Very High Very High Very High
Enkephalin 15 100.00 Very High Very High Very High
Endogenous opioid 13 100.00 Very High Very High Very High
substance P 9 100.00 Very High Very High Very High
gABA 10 99.98 Very High Very High Very High
peptic ulcer disease 56 99.84 Very High Very High Very High
narcan 50 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Gastritis 20 100.00 Very High Very High Very High
INFLAMMATION 8 100.00 Very High Very High Very High
Syndrome 15 99.98 Very High Very High Very High
Ulcers 110 99.84 Very High Very High Very High
Pain 44 99.60 Very High Very High Very High
Cancer 10 99.38 Very High Very High Very High
Headache 10 99.36 Very High Very High Very High
Disease 73 99.32 Very High Very High Very High
Infection 15 99.16 Very High Very High Very High
Rheumatoid Arthritis 6 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The high gastrin concentration following omeprazole treatment was not affected by vagotomy.
Neg (not) Regulation (affected) of gastrin
1) Confidence 0.62 Published 2010 Journal Regul. Pept. Section Abstract Doc Link 20085791 Disease Relevance 0 Pain Relevance 0
The change in serum gastrin levels relative to changes in luminal pH (using omeprazole for luminal alkalization or 0.1 N HCl for luminal acidification) was studied after oral administration of 4% lidocaine or capsaicin-induced ablation of afferent neurons.
Regulation (change) of gastrin in afferent neurons associated with qutenza and lidocaine
2) Confidence 0.62 Published 2000 Journal Dig. Dis. Sci. Section Abstract Doc Link 10877240 Disease Relevance 0 Pain Relevance 0.48
As shown previously, atropine had an identical effect on gastrin and somatostatin responses to transmural electrical stimulation of the antral region.
Regulation (effect) of gastrin associated with somatostatin
3) Confidence 0.62 Published 1984 Journal Gastroenterology Section Abstract Doc Link 6146551 Disease Relevance 0 Pain Relevance 0.32
Effect of Tityus serrulatus scorpion toxin on serum gastrin levels in anaesthetized rat.
Regulation (Effect) of gastrin associated with anesthesia
4) Confidence 0.61 Published 1998 Journal Toxicon Section Title Doc Link 9839667 Disease Relevance 0 Pain Relevance 0.10
Effects on gastric acid secretion, gastrin levels and NSAID-induced gastrotoxicity in the rat.
Regulation (Effects) of gastrin associated with cinod
5) Confidence 0.61 Published 1997 Journal Arzneimittelforschung Section Title Doc Link 9205740 Disease Relevance 0 Pain Relevance 0.18
The drug Milid does not change the serum gastrin level but suppresses the gastrin secretion in the gastric juice.
Neg (not) Regulation (change) of gastrin in gastric juice
6) Confidence 0.61 Published 1989 Journal Vutr Boles Section Abstract Doc Link 2741440 Disease Relevance 0.89 Pain Relevance 0.08
Acupuncture did not alter plasma gastrin levels (20.7 +/- 7.6 micrograms/liter, vs control 21.2 +/- 7.2 micrograms/liter) but naloxone increased it (26.1 +/- 14.5 micrograms/liter) (P < 0.05).
Neg (not) Regulation (alter) of gastrin in plasma associated with narcan and acupuncture
7) Confidence 0.61 Published 1992 Journal Dig. Dis. Sci. Section Abstract Doc Link 1345034 Disease Relevance 0 Pain Relevance 0.60
Omeprazole, a proton pump inhibitor was used for premedication for general anesthesia, and its effects on gastric secretion and serum gastrin level were investigated in 60 patients.
Regulation (effects) of gastrin associated with anesthesia
8) Confidence 0.60 Published 1992 Journal Masui Section Abstract Doc Link 1433854 Disease Relevance 0 Pain Relevance 0.18
A combination of atropine and the bombesin/GRP antagonist, like TTX, abolished the gastrin and somatostatin responses.
Regulation (responses) of gastrin associated with tetrodotoxin, antagonist and somatostatin
9) Confidence 0.59 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1348906 Disease Relevance 0 Pain Relevance 0.69
On the other hand, when hexamethonium was infused, naloxone significantly inhibited both the GRP and gastrin responses to electrical vagal stimulation.
Regulation (responses) of gastrin associated with narcan
10) Confidence 0.58 Published 1987 Journal Life Sci. Section Abstract Doc Link 2889122 Disease Relevance 0 Pain Relevance 0.88
Potent antisecretory drugs, such as omeprazole, increase serum and antral gastrin concentrations, whereas histamine H2-receptor antagonists, such as cimetidine, ranitidine, famotidine and roxatidine, have little influence on gastrin.
Neg (little) Regulation (influence) of gastrin associated with antagonist
11) Confidence 0.57 Published 1988 Journal Drugs Section Abstract Doc Link 3061768 Disease Relevance 0.54 Pain Relevance 0.28
Long-term changes in gastrin, cholecystokinin and insulin in response to oxytocin treatment.
Regulation (changes) of gastrin associated with cholecystokinin
12) Confidence 0.46 Published 1999 Journal Neuroendocrinology Section Title Doc Link 10087452 Disease Relevance 0 Pain Relevance 0.32
The transient nature of the response suggests that the vagus has not only a prompt stimulatory but also a slow inhibitory effect on gastrin release. 2) Although vagal denervation did not affect the gastrin response to anacidity, the TTX experiments revealed that both food-evoked and anacidity-evoked gastrin release depends on neural input.
Regulation (effect) of gastrin in neural associated with tetrodotoxin
13) Confidence 0.45 Published 2010 Journal Regul. Pept. Section Abstract Doc Link 20085791 Disease Relevance 0 Pain Relevance 0.26
The transient nature of the response suggests that the vagus has not only a prompt stimulatory but also a slow inhibitory effect on gastrin release. 2) Although vagal denervation did not affect the gastrin response to anacidity, the TTX experiments revealed that both food-evoked and anacidity-evoked gastrin release depends on neural input.
Neg (not) Regulation (affect) of gastrin in neural associated with tetrodotoxin
14) Confidence 0.45 Published 2010 Journal Regul. Pept. Section Abstract Doc Link 20085791 Disease Relevance 0 Pain Relevance 0.25
Since bombesin/gastrin-releasing peptide (GRP)-neurons contribute to vagally stimulated gastrin secretion, we have examined gastrin response to distention in the presence of the specific bombesin-receptor antagonist D-Phe6-BN(6-13)OMe (400 microg/kg/h: n = 10).
Regulation (response) of gastrin in neurons associated with antagonist
15) Confidence 0.45 Published 1997 Journal Regul. Pept. Section Abstract Doc Link 9163580 Disease Relevance 0 Pain Relevance 0.25
Antral gastrin contents, somatostatin contents, gastrin mRNA expression, and somatostatin mRNA expression were not significantly affected by capsaicin pretreatment.
Neg (not) Regulation (affected) of gastrin associated with qutenza and somatostatin
16) Confidence 0.45 Published 2000 Journal Dig. Dis. Sci. Section Abstract Doc Link 10877240 Disease Relevance 0 Pain Relevance 0.73
The regulation of gastrin and somatostatin secretion by intraluminal chemicals was examined in an isolated vascularly perfused rat stomach, a preparation that maintains the integrity of intramural neural pathways and the polarity of stimulation.
Regulation (regulation) of gastrin in neural associated with somatostatin
17) Confidence 0.45 Published 1984 Journal Gastroenterology Section Abstract Doc Link 6146551 Disease Relevance 0 Pain Relevance 0.13
We describe the effects of the T1 fraction purified from Tityus serrulatus scorpion venom on serum and on antral tissue gastrin levels in anaesthetized rats.
Regulation (effects) of gastrin
18) Confidence 0.45 Published 1998 Journal Toxicon Section Abstract Doc Link 9839667 Disease Relevance 0 Pain Relevance 0
Effect of galanin on gastrin and somatostatin release from the rat stomach.
Regulation (Effect) of gastrin in stomach associated with somatostatin
19) Confidence 0.45 Published 1988 Journal Life Sci. Section Title Doc Link 2453773 Disease Relevance 0 Pain Relevance 0.13
A muscle-stripped mucosal sheet obtained from rat antrum was mounted in an Ussing chamber and used to examine the regulation of gastrin and somatostatin secretion by antral neurons.
Spec (examine) Regulation (regulation) of gastrin in muscle associated with somatostatin
20) Confidence 0.45 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 2892415 Disease Relevance 0 Pain Relevance 0.21

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