INT28000

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Context Info
Confidence 0.31
First Reported 1989
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 10
Disease Relevance 3.49
Pain Relevance 5.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
hippocampal formation 2
medial 2
hippocampus 2
brain 1
Gpm6a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pyramidal cell 189 100.00 Very High Very High Very High
c fibre 4 99.84 Very High Very High Very High
Morphine 31 99.60 Very High Very High Very High
intrathecal 2 99.32 Very High Very High Very High
analgesia 9 99.20 Very High Very High Very High
Hippocampus 77 98.96 Very High Very High Very High
narcan 4 96.36 Very High Very High Very High
Central nervous system 14 91.60 High High
antinociception 3 90.24 High High
medulla 1 86.00 High High
Disease Link Frequency Relevance Heat
Stress 364 99.84 Very High Very High Very High
Repression 7 99.04 Very High Very High Very High
Urological Neuroanatomy 3 81.60 Quite High
Cognitive Disorder 7 67.60 Quite High
Renal Disease 1 60.96 Quite High
Body Weight 35 5.00 Very Low Very Low Very Low
Hypersensitivity 35 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
Volume Depletion And Dehydration 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, the BBB permeability to M6G is markedly reduced as compared with morphine, consistent with the much lower lipid solubility of M6G relative to morphine.
Negative_regulation (reduced) of M6G associated with morphine
1) Confidence 0.31 Published 1997 Journal Drug Metab. Dispos. Section Abstract Doc Link 9193881 Disease Relevance 0 Pain Relevance 1.09
Intrathecal normorphine was less potent than M6G but complete selective inhibitions of C-fibre-evoked response could be elicited by 25 micrograms and the ED50 was calculated to be 2.68 micrograms.
Negative_regulation (inhibitions) of M6G associated with c fibre and intrathecal
2) Confidence 0.29 Published 1989 Journal Brain Res. Section Abstract Doc Link 2706485 Disease Relevance 0.06 Pain Relevance 1.57
Chronic stress in male rats (3 weeks daily restraint) has regional effects: quantitative in situ hybridization demonstrated that M6a-Ib mRNA in dentate gyrus granule neurons and in CA3 pyramidal neurons is downregulated, whereas M6a-Ib mRNA in the medial prefrontal cortex is upregulated by chronic stress.
Negative_regulation (downregulated) of M6a in medial associated with stress and pyramidal cell
3) Confidence 0.24 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2629568 Disease Relevance 0.51 Pain Relevance 0.11
Downregulation of M6a mRNA in the hippocampal formation of chronically restrained rats is consistent with previous data demonstrating reduced M6a expression in the hippocampus of chronically restrained mice [8].
Negative_regulation (Downregulation) of M6a in hippocampus associated with hippocampus
4) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629568 Disease Relevance 0.41 Pain Relevance 0.22
Moreover, M6a mRNA was also downregulated in the hippocampal formation of psychosocially stressed tree shrews [11] indicating that the effect of stress on M6a expression is robustly conserved across species and is reproducible with different stress paradigms.


Negative_regulation (downregulated) of M6a in hippocampal formation associated with stress
5) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629568 Disease Relevance 0.57 Pain Relevance 0.18
M6a is downregulated by chronic stress in the hippocampus
Negative_regulation (downregulated) of M6a in hippocampus associated with stress and hippocampus
6) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629568 Disease Relevance 0.23 Pain Relevance 0.28
Chronic stress in male rats (3 weeks daily restraint) has regional effects: quantitative in situ hybridization demonstrated that M6a-Ib mRNA in dentate gyrus granule neurons and in CA3 pyramidal neurons is downregulated, whereas M6a-Ib mRNA in the medial prefrontal cortex is upregulated by chronic stress.
Negative_regulation (downregulated) of M6a in medial associated with stress and pyramidal cell
7) Confidence 0.18 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2629568 Disease Relevance 0.50 Pain Relevance 0.11
M6a initially attracted attention as a gene downregulated by stress in the hippocampal formation [7], [8].
Negative_regulation (downregulated) of M6a in hippocampal formation associated with stress
8) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629568 Disease Relevance 0.45 Pain Relevance 0.08
Stress-induced downregulation of hippocampal M6a has been confirmed in several species using quantitative real-time RT-PCR, a method that allows quantification of mRNA expression levels in homogenates from defined brain regions [8], [11].
Negative_regulation (downregulation) of M6a in brain associated with stress
9) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629568 Disease Relevance 0.53 Pain Relevance 0.07
In contrast, antisense sequences from exons 2 and 3 decreased M6G, and not morphine, analgesia.
Neg (not) Negative_regulation (decreased) of M6G associated with analgesia and morphine
10) Confidence 0.02 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9103486 Disease Relevance 0.23 Pain Relevance 1.80

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