INT28014

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Context Info
Confidence 0.77
First Reported 1989
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 34
Total Number 36
Disease Relevance 9.80
Pain Relevance 12.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Cyp3a23/3a1) endoplasmic reticulum (Cyp3a23/3a1)
Anatomy Link Frequency
joint 4
blood 1
liver 1
pituitary 1
bladder 1
Cyp3a23/3a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 3114 100.00 Very High Very High Very High
rheumatoid arthritis 550 98.66 Very High Very High Very High
Arthritis 1087 95.24 Very High Very High Very High
Inflammation 735 94.88 High High
tolerance 13 90.20 High High
Inflammatory response 25 89.20 High High
cytokine 18 85.88 High High
chemokine 57 84.84 Quite High
agonist 21 78.16 Quite High
imagery 182 77.76 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 806 99.90 Very High Very High Very High
Acidosis 114 98.96 Very High Very High Very High
Congenital Anomalies 14 97.72 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 79 97.28 Very High Very High Very High
Arthritis 1371 96.72 Very High Very High Very High
INFLAMMATION 651 94.88 High High
Hepatotoxicity 8 94.88 High High
Acid Base Imbalance 20 93.28 High High
Solid Tumor 110 91.92 High High
Toxicity 45 88.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The initial in vitro drug-release study confirmed that the Dex release is indeed dependent upon the environmental pH.
Localization (release) of Dex associated with dexamethasone
1) Confidence 0.77 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1860059 Disease Relevance 0.73 Pain Relevance 0.64
We also confirmed that the release of Dex from P-Dex was indeed pH-dependent.
Localization (release) of Dex associated with dexamethasone
2) Confidence 0.77 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860059 Disease Relevance 0.16 Pain Relevance 0.58
It usually takes longer for non-targeted polymer-drug conjugates, such as P-Dex, to be endocytosed and incorporated into the lysosomes where the acidic environment would act to release the Dex [37].
Localization (release) of Dex associated with dexamethasone
3) Confidence 0.67 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860059 Disease Relevance 0.56 Pain Relevance 0.63
In vitro Dex release
Localization (release) of Dex associated with dexamethasone
4) Confidence 0.67 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860059 Disease Relevance 0 Pain Relevance 0.20
However, the ester bond conjugation proved to be too stable to adequately release the conjugated Dex.
Localization (release) of Dex associated with dexamethasone
5) Confidence 0.67 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860059 Disease Relevance 1.00 Pain Relevance 0.57
Potentially, the in vivo Dex release may be accelerated due to the presence of various proteins that bind hydrophobic drugs.
Localization (release) of Dex associated with dexamethasone
6) Confidence 0.67 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860059 Disease Relevance 0.09 Pain Relevance 0.60
We also confirmed that the release of Dex from P-Dex was indeed pH-dependent.
Localization (release) of Dex associated with dexamethasone
7) Confidence 0.67 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860059 Disease Relevance 0.16 Pain Relevance 0.58
As shown in Figure 2, the Dex release rate depends on temperature.
Localization (release) of Dex associated with dexamethasone
8) Confidence 0.67 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860059 Disease Relevance 0 Pain Relevance 0.58
Considering the relatively slow release of Dex from P-Dex (Figure 2), one may speculate that the amount of free Dex actually needed at the arthritic joint to sustain the suppression of inflammation may be very small.
Localization (release) of Dex in joint associated with inflammation, dexamethasone and arthritis
9) Confidence 0.67 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860059 Disease Relevance 0.67 Pain Relevance 0.55
Thus, it was anticipated that the hydrazone bond would be cleaved in the low pH environment of the inflamed joint to release the conjugated Dex, thus enhancing the specificity of the delivery system.
Localization (release) of Dex in joint associated with dexamethasone
10) Confidence 0.67 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860059 Disease Relevance 0.67 Pain Relevance 0.50
Nevertheless, the overall Dex release from the conjugate was only 14% of the original loading after 14 days at 37°C (pH 5.0), or approximately 1% per day.
Localization (release) of Dex associated with dexamethasone
11) Confidence 0.67 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860059 Disease Relevance 0.07 Pain Relevance 0.55
At 37°C, Dex release under acidic pH (5.0) is 10 times faster than that released under neutral pH (7.4).
Localization (release) of Dex associated with dexamethasone
12) Confidence 0.67 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860059 Disease Relevance 0 Pain Relevance 0.54
Considering the relatively slow release of Dex from P-Dex (Figure 2), one may speculate that the amount of free Dex actually needed at the arthritic joint to sustain the suppression of inflammation may be very small.
Localization (release) of Dex in joint associated with inflammation, dexamethasone and arthritis
13) Confidence 0.67 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860059 Disease Relevance 0.68 Pain Relevance 0.55
Similarly, if some of the P-Dex was endocytosed, it would remain in the acidic lysosomal compartments and act as a drug depot to gradually release Dex for a prolonged period of time.
Localization (release) of Dex associated with dexamethasone
14) Confidence 0.67 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860059 Disease Relevance 0.55 Pain Relevance 0.55
The highest drug release occurred at 37°C in the most acidic buffer (pH 5.0), with approximately 14% of the loaded Dex released at the end of 14 days.
Localization (released) of Dex associated with dexamethasone
15) Confidence 0.67 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860059 Disease Relevance 0.41 Pain Relevance 0.59
As can be seen in Figure 2, the release of Dex from the conjugate was indeed pH-sensitive.
Localization (release) of Dex associated with dexamethasone
16) Confidence 0.67 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860059 Disease Relevance 0 Pain Relevance 0.54
The drug-releasing kinetics may be considered as zero-order within the tested time frame, which indicates that the Dex releasing rate is independent of the drug content in P-Dex.
Localization (releasing) of Dex associated with dexamethasone
17) Confidence 0.63 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860059 Disease Relevance 0.06 Pain Relevance 0.58
When the incubation temperature increased from 4°C to 37°C, the Dex releasing rate was greatly increased.
Localization (releasing) of Dex associated with dexamethasone
18) Confidence 0.63 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860059 Disease Relevance 0.05 Pain Relevance 0.55
The drug-releasing kinetics may be considered as zero-order within the tested time frame, which indicates that the Dex releasing rate is independent of the drug content in P-Dex.
Localization (releasing) of Dex associated with dexamethasone
19) Confidence 0.63 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860059 Disease Relevance 0.06 Pain Relevance 0.59
I propose that EDHF released in the mesenteric vascular bed is a cytochrome P450 (CYP)-linked, arachidonate metabolite.
Localization (released) of CYP
20) Confidence 0.60 Published 1997 Journal Am. J. Hypertens. Section Abstract Doc Link 9234831 Disease Relevance 0 Pain Relevance 0.11

General Comments

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