INT28015

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Context Info
Confidence 0.40
First Reported 1985
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 19
Total Number 22
Disease Relevance 6.32
Pain Relevance 5.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Cyp3a23/3a1) endoplasmic reticulum (Cyp3a23/3a1)
Anatomy Link Frequency
neuronal 1
plasma 1
liver 1
adult brain 1
brain 1
Cyp3a23/3a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 281 100.00 Very High Very High Very High
tolerance 19 100.00 Very High Very High Very High
intrathecal 1 100.00 Very High Very High Very High
analgesia 10 99.86 Very High Very High Very High
narcan 6 99.72 Very High Very High Very High
chemokine 19 99.64 Very High Very High Very High
electroacupuncture 12 99.56 Very High Very High Very High
Enkephalin 24 99.00 Very High Very High Very High
agonist 12 98.48 Very High Very High Very High
Dorsal horn 4 98.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperlipidemia 32 100.00 Very High Very High Very High
Cystitis 17 99.96 Very High Very High Very High
Injury 23 99.82 Very High Very High Very High
Viral Infection 8 99.68 Very High Very High Very High
Hypertension 21 99.12 Very High Very High Very High
Rheumatoid Arthritis 256 98.76 Very High Very High Very High
Adenovirus Infection 28 98.60 Very High Very High Very High
Heart Rate Under Development 10 98.44 Very High Very High Very High
Anxiety Disorder 2 96.72 Very High Very High Very High
Hypersensitivity 4 96.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The objective of this study was to identify which anesthetics when used acutely will affect cytochrome P450 (CYP) activity in male Sprague-Dawley rats in vivo.
Regulation (affect) of CYP
1) Confidence 0.40 Published 1995 Journal Pharmacology Section Abstract Doc Link 7746831 Disease Relevance 0 Pain Relevance 0.20
The present study was undertaken to examine the regulation of BF on liver cytochrome P450 (CYP) isoforms in rats.
Spec (examine) Regulation (regulation) of CYP in liver
2) Confidence 0.37 Published 2010 Journal J Asian Nat Prod Res Section Abstract Doc Link 20496194 Disease Relevance 0.10 Pain Relevance 0
Neuronal inhibition of basal glial ME production could explain the similar synergistic effects of DEX + FSK observed in all mixed neuronal/glial cultures examined, and may be important in suppressing ME production by astrocytes in the brain.
Regulation (effects) of DEX in brain associated with enkephalin
3) Confidence 0.23 Published 1996 Journal Brain Res. Section Abstract Doc Link 8883890 Disease Relevance 0 Pain Relevance 0.80
The effects of intrathecal (i.t.) phentolamine (Ph), cyproheptadine (Cyp), and naloxone (Nal), administered separately or coadministered by two of them, on the expression of Fos-like-immunoreactive (FLI) neurons were observed on both sides of the lumbar dorsal horn of rats, in which equal volumes of formalin were injected into two hindpaws and the ipsilateral dorsolateral funiculus (DLF) was transected at the thoracic level antecedently.
Regulation (effects) of Cyp in funiculus associated with dorsal horn, narcan and intrathecal
4) Confidence 0.20 Published 1999 Journal Brain Res. Section Abstract Doc Link 10350573 Disease Relevance 0.23 Pain Relevance 0.48
The aim of this study was to investigate the effect of trauma on cytochrome P450 (CYP) gene expression and to determine the role of Kupffer cells in trauma-induced alteration of CYP isozymes.
Regulation (alteration) of CYP in Kupffer cells associated with injury
5) Confidence 0.17 Published 2003 Journal Arch. Pharm. Res. Section Abstract Doc Link 14723344 Disease Relevance 0.48 Pain Relevance 0.09
In conclusion, when the serum AST value in CCl(4)-treated rats reached about 4000 IU/l, the hepatic CYP activities were one-tenth or less of the control, although the degree of decrease of the CL(tot) values varied markedly.
Regulation (control) of CYP
6) Confidence 0.14 Published 2004 Journal Int J Pharm Section Abstract Doc Link 14706259 Disease Relevance 0.14 Pain Relevance 0.07
Using a neonatal rat model, Massaro and others have demonstrated the effects of Dexamethasone (Dex) and all-trans-retinoic acid (RA) treatment on alveolar development [10].
Regulation (effects) of Dex associated with rheumatoid arthritis and dexamethasone
7) Confidence 0.12 Published 2006 Journal Respir Res Section Body Doc Link PMC1448204 Disease Relevance 0.40 Pain Relevance 0.36
This suggests that, even in Dex-treated animals that demonstrated compromised pulmonary function by other measures, exercise tolerance was not affected by hormonal treatments.


Neg (not) Regulation (affected) of Dex associated with tolerance and dexamethasone
8) Confidence 0.12 Published 2006 Journal Respir Res Section Body Doc Link PMC1448204 Disease Relevance 0.93 Pain Relevance 0.48
Possible synergistic effects of the glucocorticoid dexamethasone (DEX, 10(-7) M) and the adenylate cyclase agonist forskolin (FSK, 10(-5) M) on [Met5]enkephalin (ME) accumulation were examined in enriched rat glial cultures and in mixed neuronal/glial cultures.
Spec (Possible) Regulation (effects) of DEX in neuronal associated with agonist, enkephalin and dexamethasone
9) Confidence 0.12 Published 1996 Journal Brain Res. Section Abstract Doc Link 8883890 Disease Relevance 0 Pain Relevance 0.60
Mechanistic evaluation of changes in CYP during viral infection
Regulation (changes) of CYP associated with viral infection
10) Confidence 0.12 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.16 Pain Relevance 0
Although no direct evidence for the potentiating effect of hyperlipidemia on Dex in the HF-HD and HF-LD rats is available, Dex clearance was reported to be increased in patients taking carbamazapine [75].
Regulation (effect) of Dex associated with hyperlipidemia
11) Confidence 0.10 Published 2008 Journal Int Arch Med Section Body Doc Link PMC2414485 Disease Relevance 0.69 Pain Relevance 0.08
In order to investigate the involvement of pituitary beta-endorphin in electroacupuncture analgesia (EAA), the effects of hypophysectomy, dexamethasone (Dex) and adrenalectomy on the analgesia and the increase in plasma corticosterone (Cort) and ACTH levels produced by electroacupuncture (EA) were studied in male SD rats.
Regulation (effects) of Dex in plasma associated with dexamethasone, electroacupuncture and analgesia
12) Confidence 0.10 Published 1985 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 2993139 Disease Relevance 0.07 Pain Relevance 1.02
Effects of developmental A1254 exposure on hepatic CYP activity and adult brain PCB levels
Regulation (Effects) of CYP in adult brain
13) Confidence 0.08 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2291013 Disease Relevance 0.47 Pain Relevance 0
A similar suggestion has already been made for another chemokine, CX3CL1, and its receptor during CYP-induced cystitis [22].
Regulation (receptor) of CYP-induced associated with chemokine and cystitis
14) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 1.04 Pain Relevance 0.79
Modafinil has the potential to modulate the activities of hepatic cytochrome P450 (CYP) isoenzymes.
Regulation (modulate) of CYP
15) Confidence 0.07 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761173 Disease Relevance 0.24 Pain Relevance 0
Our results indicate that Dex acts on the NTS to elicit hypertension and tachycardia via both a GR-independent interaction with GABA(A) and GABA(B) receptors and a GR-dependent but nontranscriptional mechanism that involves activation of PI3K/Akt pathway.
Regulation (acts) of Dex associated with heart rate under development, gaba and hypertension
16) Confidence 0.06 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15523051 Disease Relevance 0.39 Pain Relevance 0.38
Although no appreciable changes in PXR and RXR mRNA levels were detected after administration of any of the vectors studied, post-translational modifications of these proteins and CYP itself such as phosphorylation, ubiquitination and redistribution between the nucleus and cytoplasm in response to virus-induced cell signaling cascades could account for the observed reduction in CYP during adenovirus infection and would not be readily detectable by the techniques used to assess changes in CYP, RXR and PXR described in this manuscript [30-32].
Regulation (changes) of CYP in nucleus associated with adenovirus infection
17) Confidence 0.06 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.25 Pain Relevance 0
Examination of the inhibitory effect of febuxostat on CYP enzymes suggested that it had minimal inhibitory effect on the activities of any CYP (Mukoyoshi et al 2008).
Regulation (effect) of CYP
18) Confidence 0.06 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643102 Disease Relevance 0.14 Pain Relevance 0.07
Treatment with the HDAd vector also did not affect ALT, but changes in CYP were still observed.
Regulation (changes) of CYP
19) Confidence 0.05 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.25 Pain Relevance 0
A helper-dependent adenoviral vector (HDAd), devoid of all viral genes and containing the E. coli beta-galactosidase transgene, was also included to fully study the effect of viral gene expression on CYP.
Regulation (effect) of CYP
20) Confidence 0.05 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.19 Pain Relevance 0

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