INT280164

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.06
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.76
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Twist1) nucleus (Twist1) DNA binding (Twist1)
transcription factor binding (Twist1)
Twist1 (Mus musculus)
Mod2 (Mus musculus)
Pain Link Frequency Relevance Heat
palliative 2 39.52 Quite Low
psoriasis 2 5.00 Very Low Very Low Very Low
Immobilon 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 58 100.00 Very High Very High Very High
Hepatocellular Cancer 40 97.24 Very High Very High Very High
Cancer 74 92.96 High High
Pancreatic Cancer 2 84.88 Quite High
Colon Cancer 2 83.88 Quite High
Skin Cancer 6 83.24 Quite High
Leukemia 2 82.44 Quite High
Uterine Cancer 2 77.20 Quite High
Liver Cancer 10 71.64 Quite High
Cirrhosis 2 45.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results demonstrated that Pa-PDT not only induces mitochondrial-mediated apoptosis, but also inhibits MDR by down-regulation of P-glycoprotein activity and expression in R-HepG2 cells.


Pa-PDT Negative_regulation (inhibits) of MDR associated with apoptosis
1) Confidence 0.06 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2731730 Disease Relevance 1.28 Pain Relevance 0
In summary, our findings provided the first evidence that PDT could inhibit the MDR activity by down-regulating the expression of P-glycoprotein via JNK activation using pheophorbide a as the photosensitizer, and our work proved that Pa-PDT inhibited the growth of MDR hepatoma cells by mitochondrial-mediated apoptosis induction.



PDT Negative_regulation (inhibit) of MDR associated with hepatocellular cancer and apoptosis
2) Confidence 0.06 Published 2009 Journal Mol Cancer Section Abstract Doc Link PMC2731730 Disease Relevance 0.48 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox