INT280190

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Context Info
Confidence 0.04
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.58
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Cbs, Hist1h1t) cell differentiation (Hist1h1t) lyase activity (Cbs)
intracellular (Hist1h1t) DNA binding (Hist1h1t) enzyme binding (Cbs)
Anatomy Link Frequency
colon 2
Cbs (Rattus norvegicus)
Hist1h1t (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 10 88.00 High High
nud 22 86.96 High High
Central nervous system 1 79.36 Quite High
Pain 7 71.20 Quite High
Antinociceptive 1 64.04 Quite High
Somatic pain 1 60.16 Quite High
Analgesic 2 31.60 Quite Low
Calcium channel 2 23.00 Low Low
Hyperalgesia 3 19.00 Low Low
Visceral pain 4 17.32 Low Low
Disease Link Frequency Relevance Heat
Nociception 6 99.48 Very High Very High Very High
INFLAMMATION 10 88.00 High High
Dyspepsia 22 86.96 High High
Pain 8 71.20 Quite High
Injury 2 54.52 Quite High
Disease 1 48.96 Quite Low
Urological Neuroanatomy 1 46.76 Quite Low
Hyperalgesia 3 19.00 Low Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

4 17.32 Low Low
Syndrome 2 6.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have confirmed previous studies on the expression of CBS and CSE in the colon and further have shown that CBS, but not CSE, is expressed by colon-specific sensory neurons (Fig. 1), where it is localized to nociceptive neurons, indicating that CBS is a major enzyme responsible for the endogenous production of H2S in these cells.
CBS Regulation (responsible) of Gene_expression (production) of H2S in colon associated with nociception
1) Confidence 0.04 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 0.58 Pain Relevance 0.32

General Comments

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