INT280193

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Context Info
Confidence 0.69
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 6.59
Pain Relevance 3.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cbs) lyase activity (Cbs) nucleolus (Cbs)
nucleus (Cbs) enzyme binding (Cbs) cytoplasm (Cbs)
Anatomy Link Frequency
neurons 4
colon 4
sensory neurons 2
proximal 2
Cbs (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 217 99.52 Very High Very High Very High
nud 154 99.26 Very High Very High Very High
Inflammation 70 98.92 Very High Very High Very High
spastic colon 70 95.92 Very High Very High Very High
Action potential 70 95.24 Very High Very High Very High
withdrawal 21 89.52 High High
Pain 49 83.48 Quite High
Central nervous system 7 74.92 Quite High
IPN 7 73.88 Quite High
Hyperalgesia 21 67.56 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 217 99.52 Very High Very High Very High
Dyspepsia 154 99.26 Very High Very High Very High
INFLAMMATION 70 98.92 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

56 95.96 Very High Very High Very High
Functional Bowel Disorder 21 95.72 Very High Very High Very High
Nociception 42 94.52 High High
Syndrome 14 92.64 High High
Pain 56 83.48 Quite High
Inflammatory Pain 7 73.88 Quite High
Hyperalgesia 21 67.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CBS expression is upregulated in the DRGs and colon in a rat model of CVH
Positive_regulation (upregulated) of Gene_expression (expression) of CBS in colon associated with nud
1) Confidence 0.69 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 1.02 Pain Relevance 0.47
We have also shown that CBS expression in both sensory neurons and the colon is dynamic and is upregulated in a model of chronic non-inflammatory visceral hypersensitivity.
Positive_regulation (upregulated) of Gene_expression (expression) of CBS in sensory neurons associated with inflammation and nud
2) Confidence 0.69 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 0.60 Pain Relevance 0.30
Our results show that CVH in this model is associated with an upregulation of CBS expression in both thoracolumbar (TL) and lumbarsacral (LS) DRG and that the use of a CBS inhibitor attenuates colonic hypersensitivity.
Positive_regulation (upregulation) of Gene_expression (expression) of CBS associated with dorsal root ganglion and nud
3) Confidence 0.69 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 1.27 Pain Relevance 1.00
Western blotting analysis showed that CBS expression was significantly increased in colon DRGs 8 weeks after neonatal AA-treatment.
Positive_regulation (increased) of Gene_expression (expression) of CBS in colon
4) Confidence 0.46 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2731739 Disease Relevance 1.17 Pain Relevance 0.93
In addition, a significant increase of CBS expression was noted in proximal and medium colon (but not distal colon) from rats with neonatal AA injection (Fig. 4C&4D).
Positive_regulation (increase) of Gene_expression (expression) of CBS in proximal
5) Confidence 0.46 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 0.69 Pain Relevance 0.35
Our results suggest that upregulation of CBS expression in colonic DRG neurons and H2S signaling may play an important role in developing CVH, thus identifying a specific neurobiological target for the treatment of CVH in functional bowel syndromes.



Positive_regulation (upregulation) of Gene_expression (expression) of CBS in neurons associated with dorsal root ganglion, syndrome and nud
6) Confidence 0.46 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2731739 Disease Relevance 1.08 Pain Relevance 0.64
The H2S-producing enzyme CBS is expressed by colonic specific DRG neurons
Positive_regulation (enzyme) of Gene_expression (expressed) of CBS in neurons associated with dorsal root ganglion
7) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 0.29 Pain Relevance 0.12

General Comments

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