INT280198

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Context Info
Confidence 0.21
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.28
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hist1h1t) chromosome (Hist1h1t) nucleus (Hist1h1t)
intracellular (Hist1h1t) DNA binding (Hist1h1t)
Hist1h1t (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcium channel 44 99.84 Very High Very High Very High
Inflammation 10 99.74 Very High Very High Very High
potassium channel 51 98.52 Very High Very High Very High
Hyperalgesia 3 77.56 Quite High
Visceral pain 4 75.88 Quite High
Somatic pain 1 64.80 Quite High
ischemia 18 63.28 Quite High
Antinociceptive 1 57.28 Quite High
agonist 6 53.52 Quite High
nud 22 50.00 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 10 99.74 Very High Very High Very High
Injury 5 93.68 High High
Urological Neuroanatomy 1 90.88 High High
Arrhythmia Under Development 33 79.96 Quite High
Hyperalgesia 3 77.56 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

4 75.88 Quite High
Pain 8 64.16 Quite High
Reperfusion Injury 9 64.04 Quite High
Cv Unclassified Under Development 21 63.28 Quite High
Nociception 6 56.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of H2S on chloride channel
Regulation (Effects) of H2S
1) Confidence 0.21 Published 2010 Journal Journal of Cardiovascular Disease Research Section Body Doc Link PMC3004170 Disease Relevance 0 Pain Relevance 0.32
Effects of H2S on Calcium channel
Regulation (Effects) of H2S associated with calcium channel
2) Confidence 0.21 Published 2010 Journal Journal of Cardiovascular Disease Research Section Body Doc Link PMC3004170 Disease Relevance 0.33 Pain Relevance 0.54
Therefore, it is reasonable to think of H2S as having an effect on T-type calcium channels, which needs further exploration.


Regulation (effect) of H2S associated with calcium channel
3) Confidence 0.12 Published 2010 Journal Journal of Cardiovascular Disease Research Section Body Doc Link PMC3004170 Disease Relevance 0 Pain Relevance 0.33
Tissue inflammation may have an influence on H2S actions.
Regulation (influence) of H2S associated with inflammation
4) Confidence 0.06 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 0.87 Pain Relevance 0.49

General Comments

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