INT2802

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Context Info
Confidence 0.59
First Reported 1979
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 2.69
Pain Relevance 7.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Asrgl1) nucleus (Asrgl1) protein maturation (Asrgl1)
cytoplasm (Asrgl1)
Anatomy Link Frequency
brain 8
liver 1
immune system 1
Asrgl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 20 100.00 Very High Very High Very High
Morphine 47 99.98 Very High Very High Very High
Physical dependence 12 99.64 Very High Very High Very High
tolerance 1 99.46 Very High Very High Very High
narcan 14 93.20 High High
withdrawal 1 92.36 High High
ketamine 2 91.20 High High
Abstinence syndrome 11 90.72 High High
Dextromethorphan 12 88.56 High High
medulla 3 82.96 Quite High
Disease Link Frequency Relevance Heat
Pancreatitis 6 99.96 Very High Very High Very High
Drug Dependence 12 99.64 Very High Very High Very High
Leukemia 2 99.50 Very High Very High Very High
Body Weight 3 93.92 High High
Hypothermia 2 90.84 High High
Syndrome 11 90.28 High High
Nociception 2 89.76 High High
Diabetes Mellitus 1 78.48 Quite High
Depression 1 75.00 Quite High
Eating Disorder 1 73.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine decreased brain and liver L-asparaginase activity and increased that of kidney.
Negative_regulation (decreased) of L-asparaginase in brain associated with morphine
1) Confidence 0.59 Published 1979 Journal Eur. J. Pharmacol. Section Abstract Doc Link 527670 Disease Relevance 0 Pain Relevance 0.60
L-Aspartic acid was found to be as effective as imipramine in reducing the effects of forced swimming, presumable by normalizing the decreased level of endogenous L-aspartic acid, due to the inhibition of L-asparaginase activity and/or by stimulating the inhibited enzyme.
Negative_regulation (inhibition) of L-asparaginase
2) Confidence 0.59 Published 1982 Journal Experientia Section Abstract Doc Link 7056352 Disease Relevance 0.18 Pain Relevance 0.07
Twenty min following the injections of 200 mg/kg D-aspartic acid, 20 mg/kg morphine, 200 mg/kg D-aspartic acid + 20 mg/kg morphine, 6 mg/kg prolyl-leucyl-glycinamide (PLG) and 6 mg/kg PLG + 20 mg/kg morphine the L-asparaginase activities of all three parts of the homozygous Brattleboro rat brains were found to be significantly inhibited.
Negative_regulation (inhibited) of L-asparaginase in brains associated with morphine
3) Confidence 0.56 Published 1984 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 6145163 Disease Relevance 0 Pain Relevance 0.88
The results were interpreted as evidence for the fact that the inhibition of the brain L-asparaginase provides and/or accelerates the biosynthesis and/or release of vasopressin.
Negative_regulation (inhibition) of brain L-asparaginase in brain
4) Confidence 0.56 Published 1984 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 6145163 Disease Relevance 0 Pain Relevance 0.88
According to the hypothesis implying that the main reason of physical dependence on opiate is the inhibition of brain L-asparaginase activity and L-aspartic acid gradually decreases compulsory opiate intake so that physical dependence disappears by itself, 31 opiate addicts were given 8 g L-aspartic acid for 7 days after withdrawal from opiate and appearance of abstinence syndrome signs.
Negative_regulation (inhibition) of L-asparaginase in brain associated with physical dependence, syndrome, opiate, withdrawal and abstinence syndrome
5) Confidence 0.50 Published 1986 Journal Arzneimittelforschung Section Abstract Doc Link 3814227 Disease Relevance 0.50 Pain Relevance 0.82
Although D-amino acids, as antipeptidases have some effects through endorphinergic systems, D-Asp (an inhibitor of L-asparaginase) seems to act at the level of L-asparaginase presumably by increasing the level of endorphins since L-Asp antagonizes the inhibitory effect of both D-Asp and morphine.
Negative_regulation (inhibitor) of L-asparaginase associated with morphine
6) Confidence 0.46 Published 1982 Journal Pol J Pharmacol Pharm Section Abstract Doc Link 7187048 Disease Relevance 0.33 Pain Relevance 0.21
It is concluded that in addition to the inhibition of the brain L-asparaginase activity which was previously hypothesized to be the main reason of the development of physical dependence on opiates as a result of the related experimental and clinical data, the inhibition by M of the brain ACE activity may take part in the development of physical dependence.
Negative_regulation (inhibition) of L-asparaginase in brain associated with physical dependence and opiate
7) Confidence 0.44 Published 1986 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 3024185 Disease Relevance 0.35 Pain Relevance 0.60
As morphine has a vasopressin releasing and a brain L-asparaginase inhibiting effect the antidiuretic action of morphine was considered to be linked to its inhibitory effect on the brain L-asparaginase.
Negative_regulation (effect) of brain L-asparaginase in brain associated with morphine
8) Confidence 0.41 Published 1984 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 6145163 Disease Relevance 0 Pain Relevance 0.69
The development of physical dependence on opiates appears to involve an inhibition by opiates of L-asparaginase and glutaminase, and the blockade by opiates of aspartatergic (ASPergic)/glutamatergic (GLUergic) receptors.
Negative_regulation (inhibition) of L-asparaginase associated with physical dependence and opiate
9) Confidence 0.41 Published 1990 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2345761 Disease Relevance 0.24 Pain Relevance 0.83
Therefore, the results were considered as further supporting evidence for the fact that the deleterious effect of M on the immune system and its functions might be related to the inhibitory effect of M on L-asparaginase activity.
Negative_regulation (effect) of L-asparaginase in immune system
10) Confidence 0.36 Published 1987 Journal Agents Actions Section Abstract Doc Link 3554913 Disease Relevance 0.07 Pain Relevance 0.14
The activities of the brain L-asparaginase and angiotensin converting enzyme (ACE), and the plasma cortisol level were found to be decreased in the rats implanted with morphine (M) containing pellets.
Negative_regulation (decreased) of L-asparaginase in brain associated with morphine
11) Confidence 0.32 Published 1986 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 3024185 Disease Relevance 0.13 Pain Relevance 0.37
Morphine decreased brain and liver L-asparaginase activity and increased that of kidney.
Negative_regulation (decreased) of L-asparaginase in liver associated with morphine
12) Confidence 0.20 Published 1979 Journal Eur. J. Pharmacol. Section Abstract Doc Link 527670 Disease Relevance 0 Pain Relevance 0.60
Of the 59 children with acute lymphoblastic leukemia (ALL) receiving E. coli L-asparaginase, 5 patients (8.5%) developed AAP.
Negative_regulation (developed) of L-asparaginase associated with leukemia and pancreatitis
13) Confidence 0.15 Published 2008 Journal Pediatr Blood Cancer Section Abstract Doc Link 18726919 Disease Relevance 0.69 Pain Relevance 0.07
According to the hypothesis that the development of physical dependence on and tolerance to opiates depends on the inhibition by opiates of L-asparaginase and L-glutaminase activities in the brain, and the blockade by opiates of the aspartatergic/glutamatergic receptors especially NMDA, four female and fourty-four male heroin addicts were included in a double-blind clinical trial.
Negative_regulation (inhibition) of L-asparaginase in brain associated with physical dependence, tolerance and opiate
14) Confidence 0.02 Published 1990 Journal Int J Clin Pharmacol Ther Toxicol Section Abstract Doc Link 2187002 Disease Relevance 0.21 Pain Relevance 0.60

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