INT28020

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.36
First Reported 1989
Last Reported 2011
Negated 0
Speculated 3
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 11.49
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Adipoq) extracellular region (Adipoq) endoplasmic reticulum (Adipoq)
Anatomy Link Frequency
plasma 1
fat 1
skeletal muscle 1
adipocytes 1
ovary 1
Adipoq (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 108 99.96 Very High Very High Very High
Enkephalin 5 95.04 Very High Very High Very High
Chronic pancreatitis 3 80.40 Quite High
Inflammation 41 63.92 Quite High
Angina 4 59.52 Quite High
tolerance 33 50.24 Quite High
agonist 32 46.32 Quite Low
Inflammatory response 5 39.16 Quite Low
Potency 4 25.00 Low Low
Antinociceptive 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 273 100.00 Very High Very High Very High
Cardiovascular Disease 121 100.00 Very High Very High Very High
Insulin Resistance 111 100.00 Very High Very High Very High
INFLAMMATION 53 100.00 Very High Very High Very High
Aging 19 100.00 Very High Very High Very High
Knee Osteoarthritis 34 99.96 Very High Very High Very High
Cancer 18 99.92 Very High Very High Very High
Necrosis 9 99.68 Very High Very High Very High
Hyperandrogenism 8 98.24 Very High Very High Very High
Obesity 388 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACKGROUND: Adiponectin is recognized as an antiinflammatory and antifibrotic protein derived from adipocytes, and low serum adiponectin levels are present in obesity.
Adiponectin Binding (recognized) of in adipocytes associated with inflammation and obesity
1) Confidence 0.36 Published 2010 Journal J. Gastroenterol. Section Abstract Doc Link 20155376 Disease Relevance 0.69 Pain Relevance 0.23
Recently it was shown that the APPL1 adaptor protein binds to the intracellular domain of adiponectin receptors and confers some of adiponectin's actions [11], and thus may be an important mediator of adiponectin-dependent insulin sensitization in skeletal muscle.
adiponectin Spec (may) Binding (binds) of in skeletal muscle
2) Confidence 0.34 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 0.89 Pain Relevance 0
Although adiponectin concentrations were not independently associated with diet, percentage body fat, or knee osteoarthritis, adiponectin was negatively associated with knee osteoarthritis scores when controlling for diet and body fat (Table 3).


adiponectin Binding (associated) of in fat associated with knee osteoarthritis and osteoarthritis
3) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945020 Disease Relevance 0.65 Pain Relevance 0.29
T was associated with significantly higher insulin resistance and CVD risk in Italian type 2 DM patients, and in French (Vasseur et al., 2002) and Swiss non-diabetic subjects (Menzaghi et al., 2002) adiponectin SNP 276G?
adiponectin SNP Binding (associated) of associated with diabetes mellitus, cardiovascular disease and insulin resistance
4) Confidence 0.23 Published 2007 Journal Nutrition Research and Practice Section Body Doc Link PMC2849047 Disease Relevance 1.56 Pain Relevance 0
The association between adiponectin SNP +276 and serum adiponectin level, insulin resistance, and CVD risk is controversial.
adiponectin SNP Binding (association) of associated with cardiovascular disease and insulin resistance
5) Confidence 0.23 Published 2007 Journal Nutrition Research and Practice Section Body Doc Link PMC2849047 Disease Relevance 1.26 Pain Relevance 0
We also examined the association between adiponectin SNP 276G?
adiponectin SNP Spec (examined) Binding (association) of
6) Confidence 0.23 Published 2007 Journal Nutrition Research and Practice Section Body Doc Link PMC2849047 Disease Relevance 1.43 Pain Relevance 0.06
In order to increase the recognition of the aminopeptidase N (APN) and dipeptidylaminopeptidase (DAP), without loss of affinity for NEP, the malonyl group of these retro-inhibitors was replaced by diversely substituted succinyl moieties.
APN Binding (recognition) of
7) Confidence 0.20 Published 1989 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 2707969 Disease Relevance 0 Pain Relevance 0.17
The association between adiponectin SNP +276 and serum adiponectin level, insulin resistance, and CVD risk is controversial.
serum adiponectin Binding (association) of associated with cardiovascular disease and insulin resistance
8) Confidence 0.20 Published 2007 Journal Nutrition Research and Practice Section Body Doc Link PMC2849047 Disease Relevance 1.28 Pain Relevance 0
target adiponectin, should be up-regulated by expressing PPAR?
adiponectin Binding (be) of
9) Confidence 0.16 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.38 Pain Relevance 0
Aging: Adiponectin, Tumor Necrosis Factor Alpha, and Insulin-Like Growth Factor-1
Adiponectin Spec (Like) Binding (Aging) of associated with necrosis, aging and cancer
10) Confidence 0.14 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3010636 Disease Relevance 1.05 Pain Relevance 0.03
Also the association between Pro12Ala and adiponectin plasma levels seems controversial: in the Japanese population Ala12 allele is associated with reduced serum adiponectin levels [94, 96] whereas no significant effect of this polymorphism on serum adiponectin was observed in polycystic ovary syndrome, healthy women, and in Asian Indians [98, 101].
adiponectin Binding (association) of in ovary associated with polycystic ovary syndrome
11) Confidence 0.06 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.90 Pain Relevance 0
This SNP has been also associated to altered plasma levels of LPL, leptin, adiponectin, and resistin.
adiponectin Binding (associated) of in plasma
12) Confidence 0.06 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 1.34 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox