INT28021

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 1989
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 42
Total Number 44
Disease Relevance 30.79
Pain Relevance 3.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Adipoq) extracellular region (Adipoq) endoplasmic reticulum (Adipoq)
Anatomy Link Frequency
plasma 8
adipocytes 4
fat 3
blood 2
monocytes 1
Adipoq (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 37 99.96 Very High Very High Very High
fibrosis 369 99.90 Very High Very High Very High
Inflammation 304 99.76 Very High Very High Very High
chemokine 11 98.28 Very High Very High Very High
tolerance 288 97.64 Very High Very High Very High
qutenza 3 97.04 Very High Very High Very High
Enkephalin 5 95.56 Very High Very High Very High
agonist 237 87.08 High High
Inflammatory response 20 42.64 Quite Low
bradykinin 6 30.08 Quite Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 1123 99.92 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

39 99.92 Very High Very High Very High
Cardiovascular Disorder Under Development 280 99.90 Very High Very High Very High
Cancer 57 99.80 Very High Very High Very High
INFLAMMATION 334 99.76 Very High Very High Very High
Weight Loss 25 99.76 Very High Very High Very High
Obesity 1411 99.68 Very High Very High Very High
Necrosis 28 99.56 Very High Very High Very High
Aging 57 99.52 Very High Very High Very High
Atherosclerosis 121 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Induction of adiponectin by natural and synthetic phenolamides in mouse and human preadipocytes and its enhancement by docosahexaenoic acid.
Positive_regulation (Induction) of adiponectin
1) Confidence 0.67 Published 2008 Journal Life Sci. Section Title Doc Link 18166202 Disease Relevance 0.09 Pain Relevance 0.18
We suggest that the beneficial results regarding atherosclerosis may be due, at least in part, to increased adiponectin.
Positive_regulation (increased) of adiponectin associated with atherosclerosis
2) Confidence 0.63 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 1.03 Pain Relevance 0
HSD1 inhibition and a concomitant increase of adiponectin levels better, we studied human primary adipocytes in culture.
Positive_regulation (increase) of adiponectin in adipocytes associated with obesity
3) Confidence 0.63 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 0.44 Pain Relevance 0.03
HSD1 inhibitor BVT116429 (30 mg/kg) increases adiponectin concentrations, both in adipocytes and, quantitatively and qualitatively, in serum.
Positive_regulation (increases) of adiponectin in adipocytes associated with obesity
4) Confidence 0.63 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 1.07 Pain Relevance 0.13
HSD1 activity or glucocorticoid concentrations demonstrate elevated adiponectin concentrations.
Positive_regulation (elevated) of adiponectin
5) Confidence 0.63 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 0.42 Pain Relevance 0
The ferulamides with an aromatic ring in the N-substituent are very active in inducing adiponectin as compared with the known active compounds, curcumin, [6]-gingerol, and capsaicin, and furthermore the activities of these ferulamides are remarkably stronger than those of the corresponding esters or the straight chain octylamide.
Positive_regulation (inducing) of adiponectin associated with qutenza
6) Confidence 0.59 Published 2008 Journal Life Sci. Section Abstract Doc Link 18166202 Disease Relevance 0.09 Pain Relevance 0.17
Total adiponectin levels were elevated in KKAy mice after treatment with both BVT116429 (30 mg/kg) and rosiglitazone compared with control (Fig. 5).
Positive_regulation (elevated) of adiponectin
7) Confidence 0.55 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 0.39 Pain Relevance 0
Increases in adiponectin concentrations may be an integral component in the mechanism of action of 11?
Positive_regulation (Increases) of adiponectin
8) Confidence 0.42 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 0.56 Pain Relevance 0
Increases in adiponectin concentrations may be an integral component in the mechanism of action of this new11?
Positive_regulation (Increases) of adiponectin
9) Confidence 0.42 Published 2008 Journal BMC Pharmacol Section Abstract Doc Link PMC2270815 Disease Relevance 0.31 Pain Relevance 0.04
Thus BVT2733, which has strong effects in the liver, likely regulates glucose homeostasis in this organ, whilst BVT116429 has less effect in the liver but upregulates the major insulin sensitizing adipokine adiponectin, due to its greater effects in the adipose tissue.


Positive_regulation (upregulates) of adiponectin in liver associated with obesity
10) Confidence 0.42 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 0.49 Pain Relevance 0
The compound 7 alone did not show a statistically significant effect on the plasma adiponectin level in KK-A(y)/Ta mice, while 1% 7 in the diets significantly lowered the blood glucose and triglyceride levels and 0.3% 7 mixed with DHA oil in the diets significantly increased the adiponectin level as compared with the control.
Positive_regulation (increased) of adiponectin in blood
11) Confidence 0.39 Published 2008 Journal Life Sci. Section Abstract Doc Link 18166202 Disease Relevance 0 Pain Relevance 0.15
In this study, it was observed that treatment with either temocapril or candesartan resulted in significant increases in adiponectin levels (Furuhashi et al 2003).
Positive_regulation (increases) of adiponectin
12) Confidence 0.39 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.90 Pain Relevance 0.03
HSD1 -/- mice and saw decreased leptin and increased adiponectin [5].
Positive_regulation (increased) of adiponectin
13) Confidence 0.37 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 0.64 Pain Relevance 0
By contrast, rosiglitazone again caused significant increases in plasma adiponectin.
Positive_regulation (increases) of adiponectin in plasma
14) Confidence 0.37 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 0.30 Pain Relevance 0
This study did not report on concentrations of adiponectin in 544-treated animals but we hypothesize that prolonged treatment with BVT116429 will demonstrate similar effects due to elevations in circulating adiponectin.
Positive_regulation (elevations) of adiponectin
15) Confidence 0.37 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 1.03 Pain Relevance 0
In a small, clinical study (Nagamia et al 2007), treatment with quinapril in comparison to placebo resulted in an increase in adiponectin, decrease in serum leptins and positive improvement on insulin sensitivity.
Positive_regulation (increase) of adiponectin
16) Confidence 0.34 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.98 Pain Relevance 0.06
an increased adipose cell size, an increased adipocyte cell number, and an imbalance
Positive_regulation (increased) of adipocyte in adipocyte
17) Confidence 0.32 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430035 Disease Relevance 0.28 Pain Relevance 0
Since pioglitazone treatment prominently increased plasma adiponectin, we also examined whether increased plasma adiponectin might explain the antifibrotic effect of pioglitazone, independent of cardiomyocyte PPAR?
Positive_regulation (increased) of plasma adiponectin in plasma
18) Confidence 0.30 Published 2008 Journal Diabetes Section Body Doc Link PMC2518499 Disease Relevance 1.18 Pain Relevance 0.43
Since pioglitazone treatment prominently increased plasma adiponectin, we also examined whether increased plasma adiponectin might explain the antifibrotic effect of pioglitazone, independent of cardiomyocyte PPAR?
Positive_regulation (increased) of plasma adiponectin in plasma
19) Confidence 0.30 Published 2008 Journal Diabetes Section Body Doc Link PMC2518499 Disease Relevance 1.18 Pain Relevance 0.44
We hypothesized that the antifibrotic effect of pioglitazone on AngII-induced cardiac fibrosis could be mediated through increases in plasma adiponectin because adiponectin overexpression has been reported to attenuate cardiac hypertrophy in mice (30) and because pioglitazone treatment increased plasma adiponectin threefold in AngII-infused cPPAR??
Positive_regulation (increases) of plasma adiponectin in plasma associated with fibrosis, coronary heart disease and cardiovascular disorder under development
20) Confidence 0.30 Published 2008 Journal Diabetes Section Body Doc Link PMC2518499 Disease Relevance 0.89 Pain Relevance 0.28

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox