INT280226

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Context Info
Confidence 0.22
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.18
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (FAAH) cytoplasm (FAAH)
Anatomy Link Frequency
colon 2
FAAH (Homo sapiens)
Pain Link Frequency Relevance Heat
Cannabinoid 14 86.04 High High
Endocannabinoid 18 70.04 Quite High
agonist 3 55.20 Quite High
Cannabinoid receptor 2 54.88 Quite High
Inflammation 17 41.60 Quite Low
corticosteroid 7 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 27 93.36 High High
INFLAMMATION 16 41.60 Quite Low
Ganglion Cysts 7 19.60 Low Low
Colitis 10 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low
Wound Healing 1 5.00 Very Low Very Low Very Low
Obesity 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest a dysregulated AEA tone in the colon of these patients, in agreement with previous findings.[20], [25] However, we observed low NAPE-PLD expression, mainly in moderate and severe-scored pancolitis patients, and no changes in the AEA-degrading enzyme FAAH, suggesting a decrease of AEA levels, as deduced by the NAPE-PLD/FAAH ratio, while D-Argenio et al. found high AEA levels in biopsy samples of colons from untreated UC patients.[25] This discrepancy may be explained by the fact that NAPE-PLD is not the only source for AEA, as others enzymes are also capable of generating AEA from NAPE, such as ?
Neg (no) Regulation (changes) of in colons Protein_catabolism (degrading) of FAAH in colon associated with inflammatory bowel disease
1) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731878 Disease Relevance 0.18 Pain Relevance 0.23

General Comments

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