INT280234

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Context Info
Confidence 0.51
First Reported 2009
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.35
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ctgf) cytosol (Ctgf) extracellular space (Ctgf)
extracellular region (Ctgf) Golgi apparatus (Ctgf) proteinaceous extracellular matrix (Ctgf)
Anatomy Link Frequency
connective tissue 2
lung 1
stem cells 1
Ctgf (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 18 67.68 Quite High
Inflammation 19 64.28 Quite High
fibrosis 37 50.00 Quite Low
Pain 24 5.00 Very Low Very Low Very Low
backache 18 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
palliative 5 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 77 99.66 Very High Very High Very High
Respiratory Syncytial Virus 102 94.64 High High
Intervertebral Disk Degeneration 93 93.52 High High
Metastasis 106 83.16 Quite High
INFLAMMATION 16 64.28 Quite High
Fibrosis 35 61.28 Quite High
Breast Cancer 34 60.96 Quite High
Cancer 127 50.00 Quite Low
Infection 23 50.00 Quite Low
Pneumonia 5 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
and hypoxia-regulated genes selected from Table 1: VEGF; CXCR4; PTHrP; IL-6, 8, 11; and CTGF.
Localization (selected) of CTGF associated with hypoxia
1) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.18 Pain Relevance 0
1, CTGF, and PDGF-C) were significantly increased by V2O5 exposure in whole lung tissue at 21 days post-exposure (Fig. 6).
Localization (increased) of CTGF in lung
2) Confidence 0.42 Published 2010 Journal Respir Res Section Body Doc Link PMC2841591 Disease Relevance 0.90 Pain Relevance 0.09
Canine notochordal-like cells have been shown to secrete connective tissue growth factor (CTGF) in culture (Erwin et al., 2006).
Localization (secrete) of CTGF in connective tissue
3) Confidence 0.37 Published 2011 Journal Disease Models & Mechanisms Section Body Doc Link PMC3008962 Disease Relevance 0.05 Pain Relevance 0
Recent advances in notochordal cell biology have demonstrated that these cells, through secretion of factors such as CTGF, can enhance matrix synthesis by other cell types, and even direct mesenchymal stem cells towards an NP-cell-like phenotype (Korecki et al., 2010).
Localization (secretion) of CTGF in stem cells
4) Confidence 0.34 Published 2011 Journal Disease Models & Mechanisms Section Body Doc Link PMC3008962 Disease Relevance 0.17 Pain Relevance 0
Canine notochordal-like cells have been shown to secrete connective tissue growth factor (CTGF) in culture (Erwin et al., 2006).
Localization (secrete) of tissue growth factor in connective tissue
5) Confidence 0.32 Published 2011 Journal Disease Models & Mechanisms Section Body Doc Link PMC3008962 Disease Relevance 0.05 Pain Relevance 0

General Comments

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