INT280263

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Context Info
Confidence 0.00
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.26
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Smad4) DNA binding (Smad4) protein complex (Smad4)
cytoplasm (Smad4) cell proliferation (Smad4) extracellular space (Proc)
Anatomy Link Frequency
nucleus 1
Smad4 (Mus musculus)
Proc (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 2 65.12 Quite High
palliative 2 36.84 Quite Low
Pain 3 26.44 Quite Low
imagery 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Immobilon 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 127 85.08 High High
Metastasis 106 80.96 Quite High
Breast Cancer 34 73.24 Quite High
Hypoxia 77 69.60 Quite High
Osteoporosis 13 51.24 Quite High
Hypercalcemia 10 27.88 Quite Low
Spontaneous Fractures 2 27.28 Quite Low
Pain 3 26.44 Quite Low
Osteolysis 9 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These factors bind to Smad4 forming a heteromeric Smad complex which translocates to the nucleus and mediates gene transcription by binding to Smad binding elements (SBEs) in the promoters of target genes [4].
Smad4 Binding (bind) of factors in nucleus
1) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.26 Pain Relevance 0.03

General Comments

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