INT280267

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Context Info
Confidence 0.11
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.45
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cxcr4) enzyme binding (Tgfb1) signal transducer activity (Cxcr4)
cytoplasm (Tgfb1) cell proliferation (Tgfb1) signal transduction (Cxcr4)
Tgfb1 (Mus musculus)
Cxcr4 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 4 99.74 Very High Very High Very High
palliative 4 72.08 Quite High
Pain 6 66.16 Quite High
imagery 6 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Immobilon 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 154 99.44 Very High Very High Very High
Breast Cancer 68 96.44 Very High Very High Very High
Cancer 254 92.16 High High
Metastasis 212 86.76 High High
Paralysis 2 68.52 Quite High
Hypercalcemia 20 66.76 Quite High
Pain 6 66.16 Quite High
Advanced Or Metastatic Breast Cancer 4 64.48 Quite High
Osteoporosis 26 59.52 Quite High
Skin Cancer 6 24.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Only vascular endothelial growth factor (VEGF) and the CXC chemokine receptor 4 (CXCR4), of 16 genes tested, were additively increased by both TGF-?
TGF Positive_regulation (increased) of CXCR4 associated with chemokine
1) Confidence 0.11 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2731927 Disease Relevance 1.77 Pain Relevance 0.19
Transcriptional activation of the VEGF and CXCR4 promoters by TGF-?
TGF Positive_regulation (activation) of CXCR4
2) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 0.68 Pain Relevance 0

General Comments

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