INT28042

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Context Info
Confidence 0.77
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 6.54
Pain Relevance 6.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Tsc22d3) cytoplasm (Tsc22d3)
Anatomy Link Frequency
neuronal 2
spine 2
macrophage 1
spinal 1
monocytes 1
Tsc22d3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 48 100.00 Very High Very High Very High
antinociception 2 99.96 Very High Very High Very High
antagonist 78 97.98 Very High Very High Very High
Morphine 1277 97.92 Very High Very High Very High
monoamine 3 97.74 Very High Very High Very High
intrathecal 2 97.26 Very High Very High Very High
cytokine 34 96.96 Very High Very High Very High
Antinociceptive 4 95.04 Very High Very High Very High
Eae 57 87.36 High High
Spinal cord 1 85.08 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 52 100.00 Very High Very High Very High
Alcoholic Liver Diseases 2 99.88 Very High Very High Very High
Sprains And Strains 574 98.72 Very High Very High Very High
Injury 94 95.56 Very High Very High Very High
Apoptosis 80 92.84 High High
Drug Dependence 96 84.32 Quite High
Choline Deficiency 6 76.84 Quite High
Nervous System Malformation 28 76.16 Quite High
Shock 64 75.12 Quite High
Endotoxemia 4 74.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, the intrathecal injections of monoamine antagonists were performed to evaluate the roles of the spinal noradrenergic and/or serotonergic systems in the production of the DSIP antinociception.
Gene_expression (production) of DSIP in spinal associated with antinociception, antagonist, monoamine and intrathecal
1) Confidence 0.77 Published 1989 Journal Brain Res. Section Abstract Doc Link 2713670 Disease Relevance 0 Pain Relevance 0.81
Dose-dependent reductions in the increase in gene expression of Tsc22d3 and Zbtb16 were observed after administration of both tested doses of RU486 (20 and 40 mg/kg, intraperitoneally).
Gene_expression (expression) of Tsc22d3
2) Confidence 0.77 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.17 Pain Relevance 0.86
Moreover, from the list of 146 probe sets, 17 transcripts exhibited co-expression with Tsc22d3 in the BXD RI panel and appeared to be co-regulated after morphine treatment.
Gene_expression (expression) of Tsc22d3 associated with morphine
3) Confidence 0.77 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.66 Pain Relevance 0.45
Expression of the Tsc22d3 gene in the BXD RI panel exhibited a strong positive correlation with 146 transcripts.
Gene_expression (Expression) of Tsc22d3
4) Confidence 0.77 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.65 Pain Relevance 0.40
Furthermore, in situ hybridization was used to analyze the brain distribution of drug-induced changes in Sgk1 and Tsc22d3 expression.
Gene_expression (expression) of Tsc22d3 in brain
5) Confidence 0.76 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0 Pain Relevance 0.44
Transfection with the GILZ shRNA (GILZsh) mix, however, caused pronounced changes in spine morphology.
Gene_expression (Transfection) of GILZ shRNA in spine
6) Confidence 0.76 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0.06 Pain Relevance 0
Strain differences in transcriptional response were also observed for TSC22 domain family 3 (Tsc22d3/Dsip1/Gilz) and CCAAT/enhancer binding protein C/EBP delta (Cebpd).
Gene_expression (/) of TSC22 domain family 3 associated with sprains and strains
7) Confidence 0.66 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.61 Pain Relevance 0.45
Strain differences in transcriptional response were also observed for TSC22 domain family 3 (Tsc22d3/Dsip1/Gilz) and CCAAT/enhancer binding protein C/EBP delta (Cebpd).
Gene_expression (/) of Tsc22d3 associated with sprains and strains
8) Confidence 0.66 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.61 Pain Relevance 0.45
Strain differences in transcriptional response were also observed for TSC22 domain family 3 (Tsc22d3/Dsip1/Gilz) and CCAAT/enhancer binding protein C/EBP delta (Cebpd).
Gene_expression (/) of Dsip1 associated with sprains and strains
9) Confidence 0.66 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.61 Pain Relevance 0.45
We also showed that knockdown of the drug-responsive genes Sgk1 and Tsc22d3 resulted in alterations to dendritic spines in mice, possibly reflecting an altered potential for plastic changes.
Gene_expression (resulted) of Tsc22d3 in spines
10) Confidence 0.65 Published 2010 Journal Genome Biol. Section Body Doc Link 20459597 Disease Relevance 0 Pain Relevance 0
Double-immunofluorescence labeling with neuronal (NeuN) and astroglial (S100B) markers was used to identify cells that expressed SGK (Sgk1) and GILZ (Tsc22d3) proteins.
Gene_expression (expressed) of GILZ in neuronal
11) Confidence 0.59 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0.07 Pain Relevance 0.24
Double-immunofluorescence labeling with neuronal (NeuN) and astroglial (S100B) markers was used to identify cells that expressed SGK (Sgk1) and GILZ (Tsc22d3) proteins.
Gene_expression (expressed) of Tsc22d3 in neuronal
12) Confidence 0.59 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0.07 Pain Relevance 0.24
Moreover, transcriptional activation of a pattern of co-expressed genes (for instance, Tsc22d3 and Nfkbia) was identified as being mediated via the glucocorticoid receptor (GR).
Gene_expression (expressed) of Tsc22d3
13) Confidence 0.52 Published 2007 Journal Genome Biol Section Abstract Doc Link PMC2394777 Disease Relevance 0.46 Pain Relevance 1.11
In alcoholic liver disease, low expression of the anti-inflammatory factor GILZ (Glucocorticoid Induced Leucin Zipper) in monocytes contributes to liver inflammation and hypersensitization to LPS.
Gene_expression (expression) of GILZ in monocytes associated with alcoholic liver diseases and inflammation
14) Confidence 0.09 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2939438 Disease Relevance 1.35 Pain Relevance 0.20
A treatment with glucocorticoids enhances GILZ expression and abrogates macrophage sensitivity to LPS and subsequent proinflammatory cytokine secretion [10].
Gene_expression (expression) of GILZ in macrophage associated with cytokine
15) Confidence 0.07 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2939438 Disease Relevance 1.23 Pain Relevance 0.30

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