INT28043

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Context Info
Confidence 0.42
First Reported 1988
Last Reported 1989
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.09
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Tsc22d3) cytoplasm (Tsc22d3)
Anatomy Link Frequency
tail 1
Tsc22d3 (Mus musculus)
Pain Link Frequency Relevance Heat
Antinociceptive 10 99.78 Very High Very High Very High
Opioid 1 98.96 Very High Very High Very High
antagonist 3 98.68 Very High Very High Very High
narcan 2 98.20 Very High Very High Very High
monoamine 3 96.92 Very High Very High Very High
intrathecal 3 96.56 Very High Very High Very High
Spinal cord 1 96.32 Very High Very High Very High
medulla 1 95.72 Very High Very High Very High
Intracerebroventricular 1 90.80 High High
Morphine 1 90.80 High High
Disease Link Frequency Relevance Heat
Nociception 1 87.44 High High
Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The antinociceptive effect of DSIP was blocked by pretreatment with the opioid antagonist, naloxone.
Negative_regulation (blocked) of DSIP associated with antagonist, narcan, opioid and antinociceptive
1) Confidence 0.42 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2853064 Disease Relevance 0.09 Pain Relevance 0.74
In the tail-pinch test, the antinociceptive effect of DSIP was significantly reduced by the pretreatment with reserpine (3 mg/kg i.p.) which depleted endogenous monoamines.
Negative_regulation (reduced) of DSIP in tail associated with antinociceptive and monoamine
2) Confidence 0.37 Published 1989 Journal Brain Res. Section Abstract Doc Link 2713670 Disease Relevance 0 Pain Relevance 0.70

General Comments

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