INT280459

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Context Info
Confidence 0.62
First Reported 2009
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 8.48
Pain Relevance 2.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk2) cytosol (Ntrk2) plasma membrane (Ntrk2)
kinase activity (Ntrk2)
Anatomy Link Frequency
neurons 2
brain 2
nociceptor 2
dorsal horn 2
Ntrk2 (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 248 99.98 Very High Very High Very High
nociceptor 101 99.84 Very High Very High Very High
spinal dorsal horn 25 99.68 Very High Very High Very High
depression 292 97.24 Very High Very High Very High
Hippocampus 172 96.64 Very High Very High Very High
Inflammation 68 96.24 Very High Very High Very High
trigeminal ganglion 225 89.04 High High
trk B 1 86.72 High High
Nerve growth factor 19 78.88 Quite High
qutenza 51 76.84 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 187 99.80 Very High Very High Very High
Down Syndrome 5 99.20 Very High Very High Very High
Death 28 97.84 Very High Very High Very High
Depression 380 97.24 Very High Very High Very High
Suicidal Behaviour 492 96.48 Very High Very High Very High
INFLAMMATION 77 96.24 Very High Very High Very High
Disease 8 94.92 High High
Hypersensitivity 74 94.60 High High
Stress 100 94.28 High High
Ganglion Cysts 265 89.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of trkB.FL and trkB.T1 is conserved across species and throughout evolution, and trkB isoform expression is regulated during development when the dominant trkB isoform expression in the brain switches from trkB.FL to trkB.T1 [39].
Regulation (regulated) of Gene_expression (expression) of trkB in brain
1) Confidence 0.62 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.63 Pain Relevance 0.20
Interestingly, we did not find changes in expression of truncated isoform of TrkB (TrkB.T1).
Neg (not) Regulation (changes) of Gene_expression (expression) of TrkB
2) Confidence 0.59 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 1.12 Pain Relevance 0.10
Moreover, altered trkB.T1 expression can affect synaptic plasticity.
Regulation (altered) of Gene_expression (expression) of trkB
3) Confidence 0.45 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.73 Pain Relevance 0.19
Moreover, altered trkB.T1 expression can affect synaptic plasticity.
Regulation (affect) of Gene_expression (expression) of trkB
4) Confidence 0.45 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.73 Pain Relevance 0.19
Here, we demonstrate that trkB.T1 mRNA and protein are both significantly up-regulated in the spinal dorsal horn following systemic antiretroviral drug administration and hind paw inflammation (Figure 1).
Regulation (regulated) of Gene_expression (mRNA) of trkB in dorsal horn associated with inflammation and spinal dorsal horn
5) Confidence 0.45 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.88 Pain Relevance 0.42
Generation of trkB.T1 wildtype and knockout mice
Regulation (Generation) of Gene_expression (wildtype) of trkB associated with targeted disruption
6) Confidence 0.45 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.43 Pain Relevance 0.07
These include indirect evidence demonstrating that antidepressants regulate BDNF/TrkB expression and that BDNF itself shows antidepressant-like effects.
Regulation (regulate) of Gene_expression (expression) of TrkB associated with antidepressant
7) Confidence 0.43 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.59 Pain Relevance 0.43
Interestingly, we did not find changes in expression of truncated isoform of TrkB (TrkB.T1).
Neg (not) Regulation (changes) of Gene_expression (expression) of TrkB
8) Confidence 0.43 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 1.12 Pain Relevance 0.10
Together these data show that Brn3a acts upstream of the Runx factors, which then repress TrkB expression to allow establishment of the non-overlapping Trk receptor profiles and correct terminally differentiated phenotypes.



Regulation (allow) of Gene_expression (expression) of TrkB
9) Confidence 0.43 Published 2010 Journal Neural Dev Section Abstract Doc Link PMC2829025 Disease Relevance 0.40 Pain Relevance 0.27
These changes are accompanied by expanded expression of TrkB in neurons that abnormally express multiple Trks, followed by the loss of TrkC and TrkA expression.
Regulation (accompanied) of Gene_expression (expression) of TrkB in neurons
10) Confidence 0.43 Published 2010 Journal Neural Dev Section Abstract Doc Link PMC2829025 Disease Relevance 0.56 Pain Relevance 0.35
Brn3a is required for Runx1 expression and the segregation of TrkA/TrkB expression in nociceptor precursors
Regulation (segregation) of Gene_expression (expression) of TrkB in nociceptor associated with nociceptor
11) Confidence 0.43 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.35 Pain Relevance 0.24
This increase suggests a potential synergistic relationship between these two neurotrophic factors in which an NGF increase may position BMSC cells to more robustly respond to BDNF through modulation of TrkB receptor expression.
Regulation (modulation) of Gene_expression (expression) of TrkB
12) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0.42 Pain Relevance 0.12
There was no effect of genetic variation in a 2500-base pair promoter region or at relevant splice junctions; however, an effect of methylation state at particular CpG dinucleotides on TrkB.T1 expression was noted.
Regulation (effect) of Gene_expression (expression) of TrkB
13) Confidence 0.26 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.50 Pain Relevance 0.04

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