INT280460

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Context Info
Confidence 0.11
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.32
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk1) plasma membrane (Ntrk1) kinase activity (Ntrk1)
cytoplasm (Ntrk1)
Ntrk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 57 99.48 Very High Very High Very High
Nerve growth factor 4 83.48 Quite High
depression 73 50.00 Quite Low
Central nervous system 5 40.56 Quite Low
long-term potentiation 2 10.64 Low Low
antidepressant 62 5.00 Very Low Very Low Very Low
Hippocampus 43 5.00 Very Low Very Low Very Low
fluoxetine 18 5.00 Very Low Very Low Very Low
Desipramine 10 5.00 Very Low Very Low Very Low
Eae 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Frailty 69 99.48 Very High Very High Very High
Congenital Anomalies 9 63.88 Quite High
Mental Disorders 6 62.00 Quite High
Depression 95 50.00 Quite Low
Hyperplasia 1 35.04 Quite Low
Suicidal Behaviour 123 14.92 Low Low
Obesity 10 14.84 Low Low
Stress 25 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 17 5.00 Very Low Very Low Very Low
Apoptosis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Male farmers differed significantly from other work classes, having a greatly increased likelihood for both TKR and THR for OA.
Positive_regulation (increased) of Localization (likelihood) of TKR associated with osteoarthritis
1) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911890 Disease Relevance 0.20 Pain Relevance 0.10
Binding of a neurotrophin to the appropriate Trk receptor leads to the dimerization and transphosphorylation of tyrosine residues in the intracellular domain of the Trk receptors and subsequent activation of cytoplasmic signaling pathways.50,51 All neurotrophins can bind to the pan75 neurotrophin receptor (p75NTR), which plays a role in neurotrophin transport, ligand binding specificity, and Trk functioning.44,52,53
Positive_regulation (appropriate) of Localization (receptor) of Trk
2) Confidence 0.07 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.13 Pain Relevance 0.11

General Comments

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