INT280461

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Context Info
Confidence 0.37
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.63
Pain Relevance 2.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
brain 2
Bdnf (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 182 94.92 High High
depression 83 94.88 High High
Hippocampus 43 94.16 High High
Glutamate 24 93.92 High High
nociceptor 2 89.60 High High
Central nervous system 7 88.20 High High
GABAergic 2 82.60 Quite High
Action potential 3 82.48 Quite High
antidepressant 62 80.20 Quite High
Opioid 12 74.04 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 24 99.08 Very High Very High Very High
Pain 238 94.92 High High
Depression 107 94.88 High High
Nociception 14 92.96 High High
Congenital Anomalies 15 86.80 High High
Stress 28 82.36 Quite High
Shock 9 64.48 Quite High
Disease 19 50.00 Quite Low
Apoptosis 7 14.56 Low Low
Suicidal Behaviour 123 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, knockout mice carrying the Val66Met polymorphism show reduced activity-dependent secretion of BDNF, without any change in the level of total BDNF.152 More interestingly, mice carrying the BDNF Met/Met or Val/Met allele show a reduced volume of hippocampus compared with wild-type mice, and BDNF Met/Met knock-in mice have reduced dendritic arbor complexity.152 These studies are quite relevant to depression, because structural abnormalities, particularly structural abnormalities in the brain, including reduced hippocampal volume during stress and in depressed patients, have been reported,153,154 which increases the risk for depression.
Negative_regulation (reduced) of Localization (secretion) of BDNF in brain associated with stress, targeted disruption, depression, congenital anomalies and hippocampus
1) Confidence 0.37 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.77 Pain Relevance 0.40
A genetic variation within the BDNF genes results in a valine to metionine substitution at codon 66 (Val66Met), resulting in reduced secretion of the BDNF protein and impaired BDNF signaling.
Negative_regulation (reduced) of Localization (secretion) of BDNF
2) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964315 Disease Relevance 0.89 Pain Relevance 1.05
Another adverse effect of reduced corticostriatal communication is the reduced release of BDNF.
Negative_regulation (reduced) of Localization (release) of BDNF
3) Confidence 0.29 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2850512 Disease Relevance 0.06 Pain Relevance 0.38
A genetic variation within the BDNF genes results in a valine to metionine substitution at codon 66 (Val66Met), resulting in reduced secretion of the BDNF protein and impaired BDNF signaling.
Negative_regulation (reduced) of Localization (secretion) of BDNF
4) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964315 Disease Relevance 0.90 Pain Relevance 1.06

General Comments

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