INT280461

Context Info Confidence 0.37 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 2.63 Pain Relevance 2.90

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)

Anatomy Link Frequency brain 2 Bdnf (Mus musculus)

Pain Link Frequency Relevance Heat Pain 182 94.92 depression 83 94.88 Hippocampus 43 94.16 Glutamate 24 93.92 nociceptor 2 89.60 Central nervous system 7 88.20 GABAergic 2 82.60 Action potential 3 82.48 antidepressant 62 80.20 Opioid 12 74.04

Disease Link Frequency Relevance Heat Targeted Disruption 24 99.08 Pain 238 94.92 Depression 107 94.88 Nociception 14 92.96 Congenital Anomalies 15 86.80 Stress 28 82.36 Shock 9 64.48 Disease 19 50.00 Apoptosis 7 14.56 Suicidal Behaviour 123 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Interestingly, knockout mice carrying the Val66Met polymorphism show reduced activity-dependent secretion of BDNF, without any change in the level of total BDNF.152 More interestingly, mice carrying the BDNF Met/Met or Val/Met allele show a reduced volume of hippocampus compared with wild-type mice, and BDNF Met/Met knock-in mice have reduced dendritic arbor complexity.152 These studies are quite relevant to depression, because structural abnormalities, particularly structural abnormalities in the brain, including reduced hippocampal volume during stress and in depressed patients, have been reported,153,154 which increases the risk for depression.

Negative_regulation (reduced) of Localization (secretion) of BDNF in brain associated with stress, targeted disruption, depression, congenital anomalies and hippocampus

1) Confidence 0.37 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.77 Pain Relevance 0.40

A genetic variation within the BDNF genes results in a valine to metionine substitution at codon 66 (Val66Met), resulting in reduced secretion of the BDNF protein and impaired BDNF signaling.

Negative_regulation (reduced) of Localization (secretion) of BDNF

2) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964315 Disease Relevance 0.89 Pain Relevance 1.05

Another adverse effect of reduced corticostriatal communication is the reduced release of BDNF.

Negative_regulation (reduced) of Localization (release) of BDNF

3) Confidence 0.29 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2850512 Disease Relevance 0.06 Pain Relevance 0.38

A genetic variation within the BDNF genes results in a valine to metionine substitution at codon 66 (Val66Met), resulting in reduced secretion of the BDNF protein and impaired BDNF signaling.

Negative_regulation (reduced) of Localization (secretion) of BDNF

4) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964315 Disease Relevance 0.90 Pain Relevance 1.06

General Comments

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