INT280462

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Context Info
Confidence 0.12
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.69
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Mecp2) embryo development (Mecp2) DNA binding (Mecp2)
protein complex (Mecp2) response to stress (Mecp2) cytoplasm (Mecp2)
Mecp2 (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 124 81.40 Quite High
depression 146 80.64 Quite High
Hippocampus 86 5.00 Very Low Very Low Very Low
fluoxetine 36 5.00 Very Low Very Low Very Low
Desipramine 20 5.00 Very Low Very Low Very Low
Central nervous system 10 5.00 Very Low Very Low Very Low
Eae 8 5.00 Very Low Very Low Very Low
Nerve growth factor 8 5.00 Very Low Very Low Very Low
midbrain 6 5.00 Very Low Very Low Very Low
amygdala 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 4 91.52 High High
Depression 190 86.40 High High
Suicidal Behaviour 246 77.88 Quite High
Stress 50 64.40 Quite High
Injury 2 55.84 Quite High
Cognitive Disorder 8 53.84 Quite High
Urological Neuroanatomy 34 5.00 Very Low Very Low Very Low
Congenital Anomalies 18 5.00 Very Low Very Low Very Low
Mental Disorders 12 5.00 Very Low Very Low Very Low
Apoptosis 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Membrane depolarization triggers the calcium-dependent phosphorylation and release of MeCP2 from BDNF promoter III, thereby facilitating transcription.177 On the other hand, membrane depolarization causes increased BDNF transcription, which involves dissociation of the MeCP2-histone deacetylase-mSin3A repression complex from its promoter,177,178 which suggests that DNA methylation-related chromatin remodeling is important for activity-dependent Bdnf gene regulation.
Positive_regulation (dependent) of Phosphorylation (phosphorylation) of MeCP2 associated with repression
1) Confidence 0.12 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.84 Pain Relevance 0.18
Membrane depolarization triggers the calcium-dependent phosphorylation and release of MeCP2 from BDNF promoter III, thereby facilitating transcription.177 On the other hand, membrane depolarization causes increased BDNF transcription, which involves dissociation of the MeCP2-histone deacetylase-mSin3A repression complex from its promoter,177,178 which suggests that DNA methylation-related chromatin remodeling is important for activity-dependent Bdnf gene regulation.
Positive_regulation (triggers) of Phosphorylation (phosphorylation) of MeCP2 associated with repression
2) Confidence 0.12 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.85 Pain Relevance 0.19

General Comments

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