INT280463

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Context Info
Confidence 0.37
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 12
Disease Relevance 4.00
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Mecp2) embryo development (Mecp2) DNA binding (Mecp2)
protein complex (Mecp2) response to stress (Mecp2) cytoplasm (Mecp2)
Anatomy Link Frequency
hypothalamus 1
arms 1
Mecp2 (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 124 88.76 High High
midbrain 36 88.48 High High
depression 146 88.00 High High
Eae 28 84.00 Quite High
long-term potentiation 14 23.56 Low Low
Hippocampus 86 5.00 Very Low Very Low Very Low
fluoxetine 36 5.00 Very Low Very Low Very Low
Desipramine 20 5.00 Very Low Very Low Very Low
Central nervous system 10 5.00 Very Low Very Low Very Low
anesthesia 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 4 99.20 Very High Very High Very High
Depression 190 93.76 High High
Body Weight 30 92.08 High High
Sprains And Strains 10 90.68 High High
Anxiety Disorder 82 89.28 High High
Tremor 20 89.12 High High
Retts Disease 340 88.12 High High
Stress 80 85.88 High High
Suicidal Behaviour 246 85.24 High High
Cognitive Disorder 18 80.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Synaptophysin and PSD95 were downregulated in the hypothalamus and syntaxin 1a and synaptotagmin were significantly decreased in the cortex of Mecp2?
Mecp2 Binding (cortex) of in hypothalamus
1) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.20 Pain Relevance 0
Home cage observations indicate that Mecp2?
Mecp2 Binding (indicate) of
2) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.15 Pain Relevance 0
At 2 weeks of age, Mecp2?
Mecp2 Binding (age) of
3) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.05 Pain Relevance 0.09
/y) on a 129S1/SvImJ (N6) or F1s of a cross between 129/SvJ Mecp2?
Mecp2 Binding (cross) of
4) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.67 Pain Relevance 0
This observational datum indicates that Mecp2?
Mecp2 Binding (indicates) of
5) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.09 Pain Relevance 0
Again, Mecp2?
Mecp2 Binding (Again) of
6) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.23 Pain Relevance 0
Comparison of the trail of footprints left by Mecp2?
Mecp2 Binding (left) of
7) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.09 Pain Relevance 0.06
At 3 weeks of age Mecp2?
Mecp2 Binding (age) of
8) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.53 Pain Relevance 0
/y-SC did not show a preference for the closed arms of the maze, but Mecp2?
Mecp2 Binding (preference) of in arms
9) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.23 Pain Relevance 0
Both the hind stride length and hind base width are significantly smaller in Mecp2?
Mecp2 Binding (smaller) of
10) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.08 Pain Relevance 0.08
Membrane depolarization triggers the calcium-dependent phosphorylation and release of MeCP2 from BDNF promoter III, thereby facilitating transcription.177 On the other hand, membrane depolarization causes increased BDNF transcription, which involves dissociation of the MeCP2-histone deacetylase-mSin3A repression complex from its promoter,177,178 which suggests that DNA methylation-related chromatin remodeling is important for activity-dependent Bdnf gene regulation.
MeCP2-histone Binding (dissociation) of associated with repression
11) Confidence 0.10 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.77 Pain Relevance 0.18
Methyl-CpG binding protein MeCP2, which encodes a protein that functions as a transcriptional repressor, selectively binds to BDNF promoter III and represses expression of the Bdnf gene.
MeCP2 Binding (binds) of
12) Confidence 0.10 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.92 Pain Relevance 0.22

General Comments

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