INT280465

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Context Info
Confidence 0.41
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.07
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Sin3a) nucleus (Sin3a) DNA binding (Sin3a)
protein complex (Sin3a) transcription factor binding (Sin3a)
Sin3a (Mus musculus)
Pain Link Frequency Relevance Heat
depression 73 80.56 Quite High
antidepressant 62 71.00 Quite High
Hippocampus 43 5.00 Very Low Very Low Very Low
fluoxetine 18 5.00 Very Low Very Low Very Low
Desipramine 10 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
Eae 4 5.00 Very Low Very Low Very Low
Nerve growth factor 4 5.00 Very Low Very Low Very Low
midbrain 3 5.00 Very Low Very Low Very Low
amygdala 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 15 100.00 Very High Very High Very High
Stress 26 82.16 Quite High
Depression 95 80.56 Quite High
Herpes Simplex Virus 2 68.08 Quite High
Suicidal Behaviour 123 67.48 Quite High
Injury 1 45.44 Quite Low
Cognitive Disorder 4 43.44 Quite Low
Urological Neuroanatomy 17 5.00 Very Low Very Low Very Low
Targeted Disruption 13 5.00 Very Low Very Low Very Low
Congenital Anomalies 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effectiveness of the Sin3 binding domain of Mad in silencing gene expression when fused to DNA binding proteins has been demonstrated in two studies.
Negative_regulation (effectiveness) of Sin3
1) Confidence 0.41 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.30 Pain Relevance 0
Membrane depolarization triggers the calcium-dependent phosphorylation and release of MeCP2 from BDNF promoter III, thereby facilitating transcription.177 On the other hand, membrane depolarization causes increased BDNF transcription, which involves dissociation of the MeCP2-histone deacetylase-mSin3A repression complex from its promoter,177,178 which suggests that DNA methylation-related chromatin remodeling is important for activity-dependent Bdnf gene regulation.
Negative_regulation (repression) of deacetylase-mSin3A associated with repression
2) Confidence 0.01 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.77 Pain Relevance 0.17

General Comments

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