INT280471

Context Info Confidence 0.33 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.14 Pain Relevance 0.10

extracellular region (BDNF) cytoplasmic membrane-bounded vesicle (BDNF)

BDNF (Homo sapiens)

Pain Link Frequency Relevance Heat Nerve growth factor 4 71.24 depression 73 50.00 Central nervous system 5 28.32 antidepressant 62 5.00 Hippocampus 43 5.00 fluoxetine 18 5.00 Desipramine 10 5.00 Eae 4 5.00 midbrain 3 5.00 amygdala 3 5.00

Disease Link Frequency Relevance Heat Mental Disorders 6 86.32 Congenital Anomalies 9 51.64 Depression 95 50.00 Hyperplasia 1 22.80 Suicidal Behaviour 123 5.00 Stress 25 5.00 Urological Neuroanatomy 17 5.00 Apoptosis 6 5.00 Targeted Disruption 6 5.00 Death 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Binding of a neurotrophin to the appropriate Trk receptor leads to the dimerization and transphosphorylation of tyrosine residues in the intracellular domain of the Trk receptors and subsequent activation of cytoplasmic signaling pathways.50,51 All neurotrophins can bind to the pan75 neurotrophin receptor (p75NTR), which plays a role in neurotrophin transport, ligand binding specificity, and Trk functioning.44,52,53

Protein_catabolism (transport) of neurotrophin

1) Confidence 0.33 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.14 Pain Relevance 0.10

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