INT280480

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Context Info
Confidence 0.25
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.14
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Ngfr) Golgi apparatus (Ngfr) cytoplasm (Ngfr)
signal transduction (Ngfr) extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
hippocampus 4
cleavage 1
Bdnf (Mus musculus)
Ngfr (Mus musculus)
Bdnf - V66M (1)
Pain Link Frequency Relevance Heat
antidepressant 332 100.00 Very High Very High Very High
depression 313 97.52 Very High Very High Very High
long-term potentiation 8 87.56 High High
Hippocampus 179 82.88 Quite High
Desipramine 43 62.52 Quite High
fluoxetine 78 61.92 Quite High
tricyclic antidepressant 1 57.60 Quite High
Endep 5 56.48 Quite High
Kinase C 4 38.60 Quite Low
positron emission tomography 1 33.68 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 25 99.56 Very High Very High Very High
Suicidal Behaviour 492 98.44 Very High Very High Very High
Depression 439 97.52 Very High Very High Very High
Death 17 49.20 Quite Low
Congenital Anomalies 36 23.48 Low Low
Stress 105 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 68 5.00 Very Low Very Low Very Low
Targeted Disruption 29 5.00 Very Low Very Low Very Low
Mental Disorders 24 5.00 Very Low Very Low Very Low
Cognitive Disorder 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, we found that one p75NTR missense polymorphism (S250L) was associated with the antidepressant response,53 and TrkB genetic variants may interact with the BDNF Val66Met polymorphism to contribute to the risk of geriatric depression.54 We also found that SNPs in glycogen synthase kinase-3beta (GSK3B), an important component in BDNF signaling, were associated with the therapeutic effects of antidepressants.55 In another study, we showed that genetic variants in plasminogen activator inhibitor type 1 gene (SERPINE1), which may be involved in the cleavage of proBDNF to mature BDNF in the brain,56 are related to MDD susceptibility and also the acute therapeutic response to antidepressants.57
BDNF (V66M) Binding (interact) of p75NTR in cleavage associated with antidepressant and depression
1) Confidence 0.25 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022309 Disease Relevance 0.18 Pain Relevance 0.61
Recently, it has been shown that pro-BDNF binds preferentially to p75NTR and elicits apoptosis as opposed to mature BDNF, which binds weakly with p75NTR but with high affinity to TrkB, where it exerts neuroprotective activity.60,225 Thus, pro-BDNF and mature BDNF cause opposite physiological actions through binding to p75NTR and TrkB receptors, respectively.55 In fact, it has been shown that pro-BDNF facilitates long-term depression via activation of p75NTR.226 On the other hand, TrkB plays a critical role in early-phase long-term potentiation227 and conversion of pro-BDNF to mature BDNF is essential for TrkB-mediated late-phase long-term potentiation.61 In a recent preliminary study, we observed that the level of pro-BDNF is increased PFC and hippocampus of suicide subjects (unpublished observation), whereas a recent genetic study suggests that the S205L polymorphism, which substitutes a serine with a leucine residue, of the p75NTR gene is associated with attempted suicide.228 These studies reveal the crucial roles of pro-BDNF and p75NTR in suicidal behavior.


BDNF Binding (binding) of p75NTR in hippocampus associated with suicidal behaviour, depression, hippocampus, long-term potentiation and apoptosis
2) Confidence 0.16 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.73 Pain Relevance 0.17
Recently, it has been shown that pro-BDNF binds preferentially to p75NTR and elicits apoptosis as opposed to mature BDNF, which binds weakly with p75NTR but with high affinity to TrkB, where it exerts neuroprotective activity.60,225 Thus, pro-BDNF and mature BDNF cause opposite physiological actions through binding to p75NTR and TrkB receptors, respectively.55 In fact, it has been shown that pro-BDNF facilitates long-term depression via activation of p75NTR.226 On the other hand, TrkB plays a critical role in early-phase long-term potentiation227 and conversion of pro-BDNF to mature BDNF is essential for TrkB-mediated late-phase long-term potentiation.61 In a recent preliminary study, we observed that the level of pro-BDNF is increased PFC and hippocampus of suicide subjects (unpublished observation), whereas a recent genetic study suggests that the S205L polymorphism, which substitutes a serine with a leucine residue, of the p75NTR gene is associated with attempted suicide.228 These studies reveal the crucial roles of pro-BDNF and p75NTR in suicidal behavior.


BDNF Binding (binds) of p75NTR in hippocampus associated with suicidal behaviour, depression, hippocampus, long-term potentiation and apoptosis
3) Confidence 0.16 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.78 Pain Relevance 0.16
Recently, it has been shown that pro-BDNF binds preferentially to p75NTR and elicits apoptosis as opposed to mature BDNF, which binds weakly with p75NTR but with high affinity to TrkB, where it exerts neuroprotective activity.60,225 Thus, pro-BDNF and mature BDNF cause opposite physiological actions through binding to p75NTR and TrkB receptors, respectively.55 In fact, it has been shown that pro-BDNF facilitates long-term depression via activation of p75NTR.226 On the other hand, TrkB plays a critical role in early-phase long-term potentiation227 and conversion of pro-BDNF to mature BDNF is essential for TrkB-mediated late-phase long-term potentiation.61 In a recent preliminary study, we observed that the level of pro-BDNF is increased PFC and hippocampus of suicide subjects (unpublished observation), whereas a recent genetic study suggests that the S205L polymorphism, which substitutes a serine with a leucine residue, of the p75NTR gene is associated with attempted suicide.228 These studies reveal the crucial roles of pro-BDNF and p75NTR in suicidal behavior.


BDNF Binding (binds) of p75NTR in hippocampus associated with suicidal behaviour, depression, hippocampus, long-term potentiation and apoptosis
4) Confidence 0.16 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.73 Pain Relevance 0.16
Recently, it has been shown that pro-BDNF binds preferentially to p75NTR and elicits apoptosis as opposed to mature BDNF, which binds weakly with p75NTR but with high affinity to TrkB, where it exerts neuroprotective activity.60,225 Thus, pro-BDNF and mature BDNF cause opposite physiological actions through binding to p75NTR and TrkB receptors, respectively.55 In fact, it has been shown that pro-BDNF facilitates long-term depression via activation of p75NTR.226 On the other hand, TrkB plays a critical role in early-phase long-term potentiation227 and conversion of pro-BDNF to mature BDNF is essential for TrkB-mediated late-phase long-term potentiation.61 In a recent preliminary study, we observed that the level of pro-BDNF is increased PFC and hippocampus of suicide subjects (unpublished observation), whereas a recent genetic study suggests that the S205L polymorphism, which substitutes a serine with a leucine residue, of the p75NTR gene is associated with attempted suicide.228 These studies reveal the crucial roles of pro-BDNF and p75NTR in suicidal behavior.


BDNF Binding (binding) of p75NTR in hippocampus associated with suicidal behaviour, depression, hippocampus, long-term potentiation and apoptosis
5) Confidence 0.16 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.73 Pain Relevance 0.17

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