INT280486

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Context Info
Confidence 0.18
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.21
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ngfr, Ntrk2) cell differentiation (Ntrk2) nuclear envelope (Ngfr)
Golgi apparatus (Ngfr) cytoplasm (Ngfr) cytosol (Ntrk2)
Anatomy Link Frequency
brain 1
hippocampus 1
Ngfr (Mus musculus)
Ntrk2 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 73 96.00 Very High Very High Very High
long-term potentiation 2 87.56 High High
Hippocampus 43 82.88 Quite High
Kinase C 1 32.92 Quite Low
antidepressant 62 15.92 Low Low
fluoxetine 18 5.00 Very Low Very Low Very Low
Bile 14 5.00 Very Low Very Low Very Low
Desipramine 10 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 6 98.30 Very High Very High Very High
Depression 95 96.00 Very High Very High Very High
Suicidal Behaviour 123 92.76 High High
Body Weight 10 82.60 Quite High
Obesity 3 67.84 Quite High
Cognitive Disorder 5 58.88 Quite High
Attention Deficit Hyperactivity Disorder 2 56.80 Quite High
Anxiety Disorder 2 54.80 Quite High
Death 4 43.52 Quite Low
Congenital Anomalies 9 17.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, it has been shown that pro-BDNF binds preferentially to p75NTR and elicits apoptosis as opposed to mature BDNF, which binds weakly with p75NTR but with high affinity to TrkB, where it exerts neuroprotective activity.60,225 Thus, pro-BDNF and mature BDNF cause opposite physiological actions through binding to p75NTR and TrkB receptors, respectively.55 In fact, it has been shown that pro-BDNF facilitates long-term depression via activation of p75NTR.226 On the other hand, TrkB plays a critical role in early-phase long-term potentiation227 and conversion of pro-BDNF to mature BDNF is essential for TrkB-mediated late-phase long-term potentiation.61 In a recent preliminary study, we observed that the level of pro-BDNF is increased PFC and hippocampus of suicide subjects (unpublished observation), whereas a recent genetic study suggests that the S205L polymorphism, which substitutes a serine with a leucine residue, of the p75NTR gene is associated with attempted suicide.228 These studies reveal the crucial roles of pro-BDNF and p75NTR in suicidal behavior.


p75NTR Binding (binding) of TrkB in hippocampus associated with suicidal behaviour, depression, hippocampus, long-term potentiation and apoptosis
1) Confidence 0.18 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.74 Pain Relevance 0.17
TrkB is a membrane-bound neurotrophin receptor that phosphorylates itself, and members of the MAPK pathway, after binding of its ligand; the brain-derived neurotrophin (Bdnf) [28], [29].
neurotrophin receptor Binding (bound) of TrkB in brain
2) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0.47 Pain Relevance 0

General Comments

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