INT28054

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Context Info
Confidence 0.14
First Reported 1989
Last Reported 2001
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.03
Pain Relevance 2.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
gonadal 1
bands 1
Ces2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 8 100.00 Very High Very High Very High
COX2 2 100.00 Very High Very High Very High
Bile 1 100.00 Very High Very High Very High
Hyperalgesia 1 99.32 Very High Very High Very High
cINOD 6 98.76 Very High Very High Very High
Pain management 1 98.68 Very High Very High Very High
central sensitization 1 96.76 Very High Very High Very High
Inflammation 3 95.72 Very High Very High Very High
Morphine 1 94.88 High High
Antihyperalgesic 1 94.64 High High
Disease Link Frequency Relevance Heat
Hyperalgesia 1 99.32 Very High Very High Very High
Pain 2 98.24 Very High Very High Very High
INFLAMMATION 6 98.04 Very High Very High Very High
Avian Sarcoma 1 95.56 Very High Very High Very High
Injury 1 87.96 High High
Hemorrhage 1 78.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Haloxon did not effect any of the serum ChE isoenzyme bands.
Neg (not) Regulation (effect) of serum ChE isoenzyme in bands
1) Confidence 0.14 Published 1996 Journal Vet Hum Toxicol Section Abstract Doc Link 8727219 Disease Relevance 0 Pain Relevance 0.13
Two sulfotransferase isoenzyme activities (acetaminophen sulfotransferase 2 and bile salt sulfotransferase I) previously shown to be regulated by gonadal hormones were also unchanged.
Regulation (regulated) of sulfotransferase isoenzyme in gonadal associated with bile and paracetamol
2) Confidence 0.04 Published 1989 Journal Dev Pharmacol Ther Section Abstract Doc Link 2714162 Disease Relevance 0 Pain Relevance 0.49
As the COX2 isoenzyme is the main target for controlling hyperalgesia, nonsteroidal anti-inflammatory drugs (NSAIDs) with high affinity for this enzyme will provide reliable antihyperalgesic effects.
Regulation (target) of COX2 isoenzyme associated with antihyperalgesic, hyperalgesia, inflammation, cinod and cox2
3) Confidence 0.01 Published 2001 Journal Acta Anaesthesiol Belg Section Abstract Doc Link 11307652 Disease Relevance 0.87 Pain Relevance 1.35
Drug inhibition and cellular regulation of prostaglandin G/H synthase isoenzyme 2.
Regulation (regulation) of synthase isoenzyme 2
4) Confidence 0.00 Published 1993 Journal J Lipid Mediat Section Title Doc Link 8357977 Disease Relevance 0.16 Pain Relevance 0.19

General Comments

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